Effect of smoking cessation on the likelihood of pancreatitis and pancreatic cancer.

IF 2.2 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Tobacco Induced Diseases Pub Date : 2024-07-12 eCollection Date: 2024-01-01 DOI:10.18332/tid/190635

Xiao Han, Zouhua Xu, Dongmei Ma, Zhi Ling, Xiaowu Dong, Xuebing Yan, Yong Chen, Guotao Lu, Xudong Yin, Hongwei Xu

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引用次数: 0

Abstract

Introduction: Tobacco smoking is a major risk factor for various diseases worldwide, including pancreatic exocrine diseases such as pancreatitis and pancreatic cancer (PC). Currently, few studies have examined the impact of smoking cessation on the likelihood of common pancreatic exocrine diseases. This study sought to determine whether smoking cessation would reduce pancreatitis and PC morbidity.

Methods: This cohort study used data from the UK Biobank (UKB) to examine the association between smoking status and the likelihood of pancreatitis and PC among 492855 participants. The subjects were divided into never smokers, ex-smokers, and current smokers. Using a multivariate-adjusted binary logistic regression model, we analyzed the relationship between different smoking conditions and the likelihood of pancreatitis and PC. Further, we studied the impact of smoking cessation on pancreatitis and PC compared with current smoking.

Results: After adjusting for potential confounders, current smokers had higher odds for acute pancreatitis (AP) (AOR=1.38; 95% CI: 1.18-1.61), chronic pancreatitis (CP) (AOR=3.29; 95% CI: 2.35-4.62) and PC (AOR=1.72; 95% CI: 1.42-2.09). People who quit smoking had comparable odds for the diseases as those who never smoked. Compared with current smokers, ex-smokers had reduced odds for AP (AOR=0.76; 95% CI: 0.64-0.89), CP (AOR=0.31; 95% CI: 0.21-0.46), and PC (AOR=0.62; 95% CI: 0.50-0.76). Subgroup analysis revealed reduced odds for these pancreatic diseases in males and females.

Conclusions: Smokers have an increased odds for pancreatitis and pancreatic cancer. Moreover, smoking cessation can significantly reduce the odds for acute pancreatitis, chronic pancreatitis and pancreatic cancer.

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戒烟对胰腺炎和胰腺癌发病几率的影响

导言：吸烟是全球各种疾病的主要风险因素，包括胰腺炎和胰腺癌（PC）等胰腺外分泌疾病。目前，很少有研究探讨戒烟对常见胰腺外分泌疾病发生几率的影响。本研究试图确定戒烟是否会降低胰腺炎和胰腺癌的发病率：这项队列研究使用了英国生物库（UKB）的数据，研究了 492855 名参与者中吸烟状况与胰腺炎和 PC 发病率之间的关系。研究对象分为从不吸烟者、曾经吸烟者和目前吸烟者。我们使用多变量调整二元逻辑回归模型，分析了不同吸烟状况与胰腺炎和 PC 可能性之间的关系。此外，我们还研究了戒烟与目前吸烟相比对胰腺炎和 PC 的影响：调整潜在混杂因素后，当前吸烟者患急性胰腺炎（AP）（AOR=1.38；95% CI：1.18-1.61）、慢性胰腺炎（CP）（AOR=3.29；95% CI：2.35-4.62）和PC（AOR=1.72；95% CI：1.42-2.09）的几率更高。戒烟者罹患这些疾病的几率与从不吸烟者相当。与当前吸烟者相比，戒烟者患 AP（AOR=0.76；95% CI：0.64-0.89）、CP（AOR=0.31；95% CI：0.21-0.46）和 PC（AOR=0.62；95% CI：0.50-0.76）的几率降低。亚组分析显示，男性和女性患这些胰腺疾病的几率降低：结论：吸烟者患胰腺炎和胰腺癌的几率增加。此外，戒烟可显著降低急性胰腺炎、慢性胰腺炎和胰腺癌的发病几率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tobacco Induced Diseases SUBSTANCE ABUSE-PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

CiteScore

5.30

自引率

5.40%

发文量

审稿时长

12 weeks

期刊介绍： Tobacco Induced Diseases encompasses all aspects of research related to the prevention and control of tobacco use at a global level. Preventing diseases attributable to tobacco is only one aspect of the journal, whose overall scope is to provide a forum for the publication of research articles that can contribute to reducing the burden of tobacco induced diseases globally. To address this epidemic we believe that there must be an avenue for the publication of research/policy activities on tobacco control initiatives that may be very important at a regional and national level. This approach provides a very important "hands on" service to the tobacco control community at a global scale - as common problems have common solutions. Hence, we see ourselves as "connectors" within this global community. The journal hence encourages the submission of articles from all medical, biological and psychosocial disciplines, ranging from medical and dental clinicians, through health professionals to basic biomedical and clinical scientists.