Prevalence of MRSA in canine and feline clinical samples from one-third of veterinary practices in Germany from 2019-2021.

IF 3.9 2区医学 Q1 INFECTIOUS DISEASES

Journal of Antimicrobial Chemotherapy Pub Date : 2024-09-03 DOI:10.1093/jac/dkae225

Leonie Feuer, Stefanie Katharina Frenzer, Roswitha Merle, Rasmus Leistner, Wolfgang Bäumer, Astrid Bethe, Antina Lübke-Becker, Babette Klein, Alexander Bartel

{"title":"Prevalence of MRSA in canine and feline clinical samples from one-third of veterinary practices in Germany from 2019-2021.","authors":"Leonie Feuer, Stefanie Katharina Frenzer, Roswitha Merle, Rasmus Leistner, Wolfgang Bäumer, Astrid Bethe, Antina Lübke-Becker, Babette Klein, Alexander Bartel","doi":"10.1093/jac/dkae225","DOIUrl":null,"url":null,"abstract":"Background: MRSA is a major contributor to AMR-related deaths. The WHO's global action plan emphasizes a One Health approach, acknowledging the connection between humans and their companion animals. It is agreed on that comprehensive AMR surveillance is needed.Objectives: This study provides a large-scale overview of MRSA occurrence in cats and dogs in Germany, serving as a foundation for continuous surveillance.Methods: The study analysed all results of canine and feline bacterial diagnostic samples from a large laboratory, encompassing samples received from veterinary practices between January 2019 and December 2021. MRSA prevalence between host species, sample types and geographical distribution were compared. Additionally, data were contrasted with human MRSA surveillance data from Germany.Results: Samples originated from 3491 German veterinary practices, representing 33.1% of practices and clinics nationally. Bacterial examination results from 175 171 samples were analysed, identifying S. aureus in 5526 of these samples (3.2% isolation rate). S. aureus in clinical samples was more prevalent in cats (5.6%) than dogs (2.0%). Methicillin resistance was found in 17.8% of S. aureus samples and was higher in dogs (20.4%, 95%CI 18.9-22.0) than cats (15.6%, 95%CI 14.3-17.0). The highest MRSA prevalence was found in canine wound samples (32%), compared to skin/soft tissue, respiratory tract and other (<23% respectively).Conclusion: The study reveals a 17.8% MRSA prevalence, which is higher than the human outpatient MRSA prevalence (5.4%). Restriction and regulation of veterinary antibiotic use should be validated with AMR surveillance. Our study shows that this is feasible in companion animals with significant coverage.","PeriodicalId":14969,"journal":{"name":"Journal of Antimicrobial Chemotherapy","volume":null,"pages":null},"PeriodicalIF":3.9000,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Antimicrobial Chemotherapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/jac/dkae225","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Background: MRSA is a major contributor to AMR-related deaths. The WHO's global action plan emphasizes a One Health approach, acknowledging the connection between humans and their companion animals. It is agreed on that comprehensive AMR surveillance is needed.

Objectives: This study provides a large-scale overview of MRSA occurrence in cats and dogs in Germany, serving as a foundation for continuous surveillance.

Methods: The study analysed all results of canine and feline bacterial diagnostic samples from a large laboratory, encompassing samples received from veterinary practices between January 2019 and December 2021. MRSA prevalence between host species, sample types and geographical distribution were compared. Additionally, data were contrasted with human MRSA surveillance data from Germany.

Results: Samples originated from 3491 German veterinary practices, representing 33.1% of practices and clinics nationally. Bacterial examination results from 175 171 samples were analysed, identifying S. aureus in 5526 of these samples (3.2% isolation rate). S. aureus in clinical samples was more prevalent in cats (5.6%) than dogs (2.0%). Methicillin resistance was found in 17.8% of S. aureus samples and was higher in dogs (20.4%, 95%CI 18.9-22.0) than cats (15.6%, 95%CI 14.3-17.0). The highest MRSA prevalence was found in canine wound samples (32%), compared to skin/soft tissue, respiratory tract and other (<23% respectively).

Conclusion: The study reveals a 17.8% MRSA prevalence, which is higher than the human outpatient MRSA prevalence (5.4%). Restriction and regulation of veterinary antibiotic use should be validated with AMR surveillance. Our study shows that this is feasible in companion animals with significant coverage.

查看原文本刊更多论文

2019-2021 年德国三分之一兽医诊所犬科和猫科临床样本中 MRSA 的流行率。

背景：MRSA 是造成急性呼吸道感染相关死亡的主要原因。世卫组织的全球行动计划强调 "一体健康 "方法，承认人类与其伴侣动物之间的联系。人们一致认为需要对AMR进行全面监控：本研究概述了德国猫和狗中 MRSA 的发生情况，为持续监控奠定了基础：该研究分析了一家大型实验室的犬科和猫科细菌诊断样本的所有结果，包括 2019 年 1 月至 2021 年 12 月期间从兽医诊所收到的样本。比较了宿主物种、样本类型和地理分布之间的 MRSA 感染率。此外，还将数据与德国的人类 MRSA 监测数据进行了对比：样本来自 3491 家德国兽医诊所，占全国诊所总数的 33.1%。对 175 171 份样本的细菌检查结果进行了分析，在其中的 5526 份样本中发现了金黄色葡萄球菌（分离率为 3.2%）。临床样本中猫（5.6%）的金黄色葡萄球菌感染率高于狗（2.0%）。在 17.8% 的金黄色葡萄球菌样本中发现了甲氧西林耐药性，狗（20.4%，95%CI 18.9-22.0）的耐药性高于猫（15.6%，95%CI 14.3-17.0）。犬伤口样本中的 MRSA 感染率最高（32%），而皮肤/软组织、呼吸道和其他样本中的感染率较低：研究显示 MRSA 感染率为 17.8%，高于人类门诊 MRSA 感染率（5.4%）。兽用抗生素使用的限制和监管应通过 AMR 监测来验证。我们的研究表明，这在伴侣动物中是可行的，而且覆盖面很广。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Antimicrobial Chemotherapy 医学-传染病学

CiteScore

9.20

自引率

5.80%

发文量

423

审稿时长

2-4 weeks

期刊介绍： The Journal publishes articles that further knowledge and advance the science and application of antimicrobial chemotherapy with antibiotics and antifungal, antiviral and antiprotozoal agents. The Journal publishes primarily in human medicine, and articles in veterinary medicine likely to have an impact on global health.