Desmopressin nasal spray inhibiting parasympathetic function on isolated tracheal smooth muscle.

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
ACS Applied Electronic Materials Pub Date : 2024-07-08 eCollection Date: 2024-01-01 DOI:10.7150/ijms.98166
Ying-Liang Chou, Hsing-Won Wang
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Abstract

Objectives: Nocturia with or without asthma is one of the aging diseases. Desmopressin has been used as a nasal spray for patients who are suffering from nocturia. This study determined the effects of desmopressin on isolated tracheal smooth muscle in vitro. Methods: We evaluated desmopressin's efficiency on isolated rat tracheal smooth muscle. Desmopressin was evaluated for the following effects on tracheal smooth muscle: (1) effect on resting tension; (2) effect on contraction brought on by parasympathetic mimetic 10-6 M methacholine; and (3) effect on electrically produced tracheal smooth muscle contractions. Results: As the concentration grew, desmopressin by itself had no impact on the trachea's baseline tension. Addition of desmopressin at doses of 10-5 M or above elicited a significant relaxation response to 10-6 M methacholine-induced contraction. Desmopressin could also inhibit spike contraction of the trachea induced by electrical field. Conclusion: According to this study, desmopressin at high quantities may prevent the trachea's parasympathetic activity. Due to its ability to block parasympathetic activity and lessen the contraction of the tracheal smooth muscle brought on by methacholine, Desmopressin nasal spray might help nocturia sufferers experience fewer asthma attacks.

去氨加压素鼻喷雾剂对离体气管平滑肌副交感神经功能的抑制作用
目的:伴有或不伴有哮喘的夜尿症是老年疾病之一。去氨加压素已被用作夜尿症患者的鼻腔喷雾剂。本研究测定了去氨加压素对离体气管平滑肌的影响。方法:我们评估了去氨加压素对离体大鼠气管平滑肌的作用。去氨加压素对气管平滑肌的影响包括:(1)对静息张力的影响;(2)对副交感神经模拟物 10-6 M 甲氧胆碱引起的收缩的影响;以及(3)对电刺激气管平滑肌收缩的影响。结果:随着浓度的增加,去氨加压素本身对气管的基线张力没有影响。加入剂量为 10-5 M 或更高的去氨加压素会对 10-6 M 甲氧胆碱引起的收缩产生明显的松弛反应。去氨加压素还能抑制电场引起的气管尖峰收缩。结论根据这项研究,大量去氨加压素可阻止气管的副交感神经活动。由于去氨加压素能够阻断副交感神经的活动,减轻甲氧胆碱引起的气管平滑肌收缩,因此去氨加压素鼻腔喷雾剂可帮助夜尿症患者减少哮喘发作。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
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