Synthesis of polysubstituted pyrazoles and their biological applications

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2024-07-17 DOI:10.1080/00397911.2024.2377283

Appalanaidu Satipidakala , Ramakrishna Rao Bhonsle , Ramana Tamminana

引用次数: 0

Abstract

Novel library of pyrazole derivatives (6a–k) from substituted 4-dioxaborolanyl-1H-pyrazole and halo benzaldehyde through simultaneous Suzuki reaction, nucleophilic addition, and hydrolysis under moderate reaction conditions. The desired compounds 6a–k have been formed in good to high yield. All the compound structures were characterized by analytical and spectral (¹H NMR,¹³C NMR and MS) studies. Furthermore, the evaluation of biological activity of synthesized molecules.

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多取代吡唑的合成及其生物应用

新型吡唑衍生物库（6a-k）由取代的 4-二氧杂戊硼酰-1H-吡唑和卤代苯甲醛通过同时发生的铃木反应、亲核加成和水解反应在湿度和温度条件下生成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.