Gene-Environment Interactions and Gene–Gene Interactions on Two Biological Age Measures: Evidence from Taiwan Biobank Participants (Adv. Biology 7/2024)

IF 3.2 3区生物学 Q3 MATERIALS SCIENCE, BIOMATERIALS

Advanced biology Pub Date : 2024-07-12 DOI:10.1002/adbi.202470071

Wan-Yu Lin

引用次数: 0

Abstract

Gene-Environment Interactions

Gene-environment interactions on PhenoAgeAccel (age-adjusted PhenoAge) were searched through variance quantitative trait loci (vQTLs) analyses of 111,996 Taiwan Biobank participants. A total of 4 nearly independent vQTLs were identified with p < 5E-8. Further studies showed that smoking exacerbated the vQTLs' aging effects, while higher educational attainment attenuated these effects. More details can be found in article number 2400149 by Wan-Yu Lin.

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基因-环境相互作用和基因-基因相互作用对两种生物年龄测量的影响：来自台湾生物库参与者的证据（Adv. Biology 7/2024）

基因与环境的相互作用通过对111,996名台湾生物库参与者进行方差数量性状位点（vQTLs）分析，研究了基因与环境在PhenoAgeAccel（年龄调整后的PhenoAge）上的相互作用。结果发现了 4 个几乎独立的 vQTLs，p 值为 5E-8。进一步的研究表明，吸烟会加剧vQTLs的衰老效应，而较高的教育程度则会减弱这些效应。更多详情，请参阅林婉玉（Wan-Yu Lin）撰写的编号为 2400149 的文章。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced biology Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

6.60

自引率

0.00%

发文量

130