Changes in the gut microbiota of pseudoxanthoma elasticum patients

IF 3.1 4区 医学 Q2 DERMATOLOGY
M. Berard , K. Chassain , C. Méry , F. Gillaizeau , T. Carton , H. Humeau , N. Navasiolava , S. Rocour , L. Schurgers , M. Kempf , L. Martin
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引用次数: 0

Abstract

Objective

Pseudoxanthoma elasticum (PXE) is a rare autosomal disorder with a variable phenotype that may be modulated by environmental factors. Plasma vitamin K (VK) levels may be involved in the ectopic calcification process observed in PXE. Since VK2 is predominantly produced by the gut microbiota, we hypothesized that changes in the gut microbiota of PXE patients might exacerbate the calcification process and disease symptoms.

Methods

Twenty PXE patients were included in the study and 60 gut microbiota profiles from the Biofortis laboratory database were used as controls.

Results

The Rhodospirillaceae family was more abundant in the PXE group while the Sphingomonadaceae family was more abundant in the control group. In a PXE severity subgroup analysis, microbiota dispersion was lower in “severe” than in “non-severe” patients, which was confirmed by permutation multivariate analysis of variance at the phylum, family and genus ranks. However, no significant association was found in a model incorporating relative abundance of bacterial families, severity score, and different blood and fecal VK species.

Conclusion

These results suggest slight compositional changes in the gut microbiota of PXE patients. Further studies are needed to substantiate their impact on VK metabolism and the calcification process.

假黄瘤患者肠道微生物群的变化
目的假黄疽(PXE)是一种罕见的常染色体疾病,其表型多变,可能受环境因素的影响。血浆维生素 K(VK)水平可能与 PXE 中观察到的异位钙化过程有关。由于 VK2 主要由肠道微生物群产生,我们推测 PXE 患者肠道微生物群的变化可能会加剧钙化过程和疾病症状。结果 在 PXE 组中,Rhodospirillaceae 家族的数量较多,而在对照组中,Sphingomonadaceae 家族的数量较多。在 PXE 严重程度亚组分析中,"重度 "患者的微生物群分散度低于 "非重度 "患者,这一点在门、科和属的包络多变量方差分析中得到了证实。结论:这些结果表明,PXE 患者肠道微生物群的组成发生了轻微变化。这些结果表明 PXE 患者肠道微生物群的组成发生了轻微变化,需要进一步研究以证实其对 VK 代谢和钙化过程的影响。
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来源期刊
CiteScore
1.40
自引率
0.00%
发文量
70
审稿时长
81 days
期刊介绍: Les Annales de dermatologie sont le rendez-vous mensuel incontournable de toute la dermatologie francophone, grâce à leur comité de rédaction qui assure une sélection rigoureuse des articles selon les normes de l''édition scientifique internationale. Une revue didactique, véritable aide à la pratique médicale quotidienne Pour compléter et enrichir la partie scientifique, la rubrique Formation médicale continue propose aux lecteurs des textes didactiques et interactifs (Cas pour diagnostic, Notes de pharmacovigilance, la Question du praticien, Dermatologie chirurgicale, la Sélection bibliographique du mois...) qui les font bénéficier d''une formation post-universitaire diversifiée et de qualité. La revue consacre également un espace pour la publication de questions des lecteurs auxquelles des experts apportent une réponse.
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