A non-invasive screening method using Caenorhabditis elegans for early detection of multiple cancer types: A prospective clinical study

IF 2.3 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Hideyuki Hatakeyama, Masayo Morishita, Aya Hasan Alshammari, Umbhorn Ungkulpasvich, Junichi Yamaguchi, Takaaki Hirotsu, Eric di Luccio
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引用次数: 0

Abstract

Cancer is the second leading cause of death worldwide, according to the World Health Organization, surpassed only by cardiovascular diseases. Early identification and intervention can significantly improve outcomes. However, finding a universal, non-invasive, economical, and precise method for early cancer detection remains a significant challenge. This study explores the efficacy of an innovative cancer detection test, N-NOSE, leveraging a Caenorhabditis elegans olfactory assay on urine samples across a diverse patient group exceeding 1600 individuals diagnosed with various cancers, with samples from the Shikoku Cancer Center (Ehime, Japan) under approved ethical standards. Current cancer screening techniques often require invasive procedures, can be painful or complex, with poor performance, and might be prohibitively costly, limiting accessibility for many. N-NOSE addresses these challenges head-on by offering a test based on urine analysis, eliminating the need for invasive methods, and being more affordable with higher performance at early stages than extensive blood tests or comprehensive body scans for cancer detection. In this study, N-NOSE demonstrated a capability to accurately identify upwards of 20 cancer types, achieving detection sensitivities between 60 and 90 %, including initial-stage cancers. The findings robustly advocate for N-NOSE's potential as a revolutionary, cost-effective, and minimally invasive strategy for broad-spectrum early cancer detection. It is also particularly significant in low- and middle-income countries with limited access to advanced cancer diagnostic methods, which may contribute to the improved outcome of affected individuals.

利用秀丽隐杆线虫对多种癌症类型进行早期检测的无创筛查方法:前瞻性临床研究
世界卫生组织称,癌症是全球第二大死因,仅次于心血管疾病。早期识别和干预可以大大改善预后。然而,寻找一种通用、无创、经济、精确的早期癌症检测方法仍是一项重大挑战。这项研究探讨了创新型癌症检测试验 N-NOSE 的功效,该试验利用了一种秀丽隐杆线虫嗅觉检测法,对超过 1600 名确诊为各种癌症的不同患者群体的尿液样本进行检测,样本来自符合伦理标准的四国癌症中心(日本爱媛县)。目前的癌症筛查技术通常需要侵入性程序,可能很痛苦或很复杂,而且性能不佳,成本可能高得令人望而却步,从而限制了许多人的使用。N-NOSE 通过提供一种基于尿液分析的检测方法迎刃而解了这些挑战,这种检测方法无需采用侵入性方法,而且与用于癌症检测的大量血液检测或全面身体扫描相比,它更经济实惠,在早期阶段具有更高的性能。在这项研究中,N-NOSE 展示了准确识别多达 20 多种癌症类型的能力,检测灵敏度在 60% 到 90% 之间,包括初期癌症。这些研究结果有力地证明了 N-NOSE 作为一种革命性的、具有成本效益的、微创的广谱早期癌症检测策略的潜力。它在中低收入国家的意义也尤为重大,因为这些国家获得先进癌症诊断方法的机会有限,这可能有助于改善患者的预后。
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来源期刊
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
4.60
自引率
0.00%
发文量
191
审稿时长
59 days
期刊介绍: Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.
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