Prevalence and factors associated with intestinal parasitic infections among preschool-aged children in Ethiopia: A systematic review and meta-analysis

IF 2 Q3 INFECTIOUS DISEASES

Parasite Epidemiology and Control Pub Date : 2024-07-08 DOI:10.1016/j.parepi.2024.e00368

Abayeneh Girma, Amere Genet

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引用次数: 0

Abstract

Intestinal parasitic infections (IPIs) pose a serious public health threat across the globe, particularly in children residing in poor and most deprived communities like Ethiopia. Many published articles were available separately, and a detailed nationwide review was essential to combine all the results to draw a conclusion and avoid any informational conflicts, ambiguities, or misunderstandings. Therefore, this systematic review and meta-analysis aimed to provide pooled estimates for the individually available data on IPIs and its determinant factors among preschool-aged children (PSAC) in Ethiopia. Published and unpublished articles from various electronic databases were accessed using MeSH terms and keywords. I² and sensitivity analysis tests were used to assess potential sources of heterogeneity across studies. Funnel plot, Begg's, and Egger's regression tests were used to check publication bias. A random-effects model with a 95% confidence interval (CI) was used to calculate the pooled estimate of IPI. In this meta-analysis, a total of 14,994 PSAC were included in the 32 eligible studies. The pooled national prevalence of IPIs among PSAC was 32.52% (95% CI: 26.24, 38.80). Of these, single and mixed infections contribute 31.08% and 1.44%, respectively. According to the subgroup analysis, the highest prevalence was observed in simple random studies (39.61%; 95% CI: 29.19, 50.03), the Tigray region (58.00%; 95% CI: 54.10, 61.90), studies conducted in >384 (39.47%; 95% CI: 27.73, 51.20) sample sizes, cross-sectional studies (32.76%), community-based studies (42.33%; 95% CI: 31.93, 52.74), and from 2005 to 2016 (34.53%; 95% CI: 20.13, 48.92) study periods. Intestinal parasites were significantly associated with eating raw fruits and vegetables (aOR = 3.21; 95%CI: 1.11–5.31). The high prevalence of STHs observed in this systematic review and meta-analysis underscores the need for appropriate control and prevention strategies suitable for PSAC in Ethiopia.

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埃塞俄比亚学龄前儿童肠道寄生虫感染的流行率和相关因素：系统回顾和荟萃分析

肠道寄生虫感染（IPIs）在全球范围内构成了严重的公共卫生威胁，尤其是对居住在埃塞俄比亚等贫穷落后社区的儿童而言。许多已发表的文章都是单独发表的，因此有必要在全国范围内进行详细综述，以便综合所有结果得出结论，避免任何信息冲突、歧义或误解。因此，本系统综述和荟萃分析旨在对埃塞俄比亚学龄前儿童（PSAC）IPIs 及其决定因素的个别可用数据进行汇总估算。使用 MeSH 术语和关键词从各种电子数据库中检索已发表和未发表的文章。使用 I2 和敏感性分析测试来评估各研究之间潜在的异质性来源。漏斗图、Begg's 和 Egger's 回归检验用于检查发表偏倚。采用带有 95% 置信区间 (CI) 的随机效应模型来计算 IPI 的汇总估计值。在这项荟萃分析中，32 项符合条件的研究共纳入了 14,994 例 PSAC。汇总的全国 PSAC IPI 感染率为 32.52% (95% CI: 26.24, 38.80)。其中，单一感染和混合感染分别占 31.08% 和 1.44%。根据亚组分析，简单随机研究（39.61%；95% CI：29.19，50.03）、提格雷地区（58.00%；95% CI：54.10，61.90）、>384（39.47%；95% CI：27.73，51.20）样本量、横断面研究（32.76%）、基于社区的研究（42.33%；95% CI：31.93，52.74）以及 2005 年至 2016 年（34.53%；95% CI：20.13，48.92）研究期间进行的研究。肠道寄生虫与生吃水果和蔬菜明显相关（aOR = 3.21；95%CI：1.11-5.31）。本系统综述和荟萃分析所观察到的 STHs 高流行率突出表明，需要制定适合埃塞俄比亚 PSAC 的适当控制和预防策略。

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来源期刊

Parasite Epidemiology and Control Medicine-Infectious Diseases

CiteScore

5.70

自引率

3.10%

发文量

审稿时长

17 weeks

期刊介绍： Parasite Epidemiology and Control is an Open Access journal. There is an increasing amount of research in the parasitology area that analyses the patterns, causes, and effects of health and disease conditions in defined populations. This epidemiology of parasite infectious diseases is predominantly studied in human populations but also spans other major hosts of parasitic infections and as such this journal will have a broad remit. We will focus on the major areas of epidemiological study including disease etiology, disease surveillance, drug resistance and geographical spread and screening, biomonitoring, and comparisons of treatment effects in clinical trials for both human and other animals. We will also look at the epidemiology and control of vector insects. The journal will also cover the use of geographic information systems (Epi-GIS) for epidemiological surveillance which is a rapidly growing area of research in infectious diseases. Molecular epidemiological approaches are also particularly encouraged.