Sebaceous Carcinoma with Involvement of the Oral Cavity: A Case Report of a Rare Occurrence

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Dr. Hisham Alshuaibi , Prof Mohammed Islam , Dr. Sarah Fitzpatrick , Prof. Indraneel Bhattacharyya
{"title":"Sebaceous Carcinoma with Involvement of the Oral Cavity: A Case Report of a Rare Occurrence","authors":"Dr. Hisham Alshuaibi ,&nbsp;Prof Mohammed Islam ,&nbsp;Dr. Sarah Fitzpatrick ,&nbsp;Prof. Indraneel Bhattacharyya","doi":"10.1016/j.oooo.2024.04.038","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Sebaceous carcinoma (SC) is an aggressive, rare cutaneous malignancy. It shows striking predilection for the skin of the eyelid, face, neck, and scalp, but may arise on any cutaneous site.. Extraorbital sites overall account for only approximately 25% of SCl, and the head and neck region is involved in 70% of cases. Involvement of the oral cavity in SC is rare. Hereby we present a case of cutaneous SC with direct extension and involvement of the oral mucosa.</p></div><div><h3>Case presentation</h3><p>A 25-year-old male presented with a painless ulcerated lesion on the left commissure area persisting for a duration of 3 months. The past medical history was unremarkable. Extra-oral examination showed a markedly ulcerated, exophytic, irregularly shaped mass of the left commissure extending to the labial and buccal mucosa. The lesion straddled the point of transition between mucosa and skin. The clinical differential diagnosis included squamous cell carcinoma, basal cell carcinoma, and salivary gland malignancy. On histopathological examination, a poorly differentiated malignant epithelial neoplasm with sebaceous differentiation was identified. Upon immunohistochemical testing, the neoplastic cells were strongly reactive for AE1/3, EMA, and CD15. In addition, CAM 5.2 and Ber-EP4 were also focally positive toward the periphery of the neoplastic islands. SOX10 was negative. The final diagnosis of sebaceous carcinoma was rendered. The patient was referred for oncologic treatment but lost to follow-up.</p></div><div><h3>Conclusion</h3><p>This case illustrates a rare case of SC with extension beyond its typical cutaneous boundaries into the oral mucosa. The presentation of SC in this manner underscores the complexity of diagnosing and managing such uncommon manifestations of skin cancers. This case reinforces that SC should be included in the differential diagnosis of lesions involving both skin and oral cavity and careful evaluation of both histopathology as well as immunohistochemistry is essential for accurate diagnosis.</p></div>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212440324002153","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction

Sebaceous carcinoma (SC) is an aggressive, rare cutaneous malignancy. It shows striking predilection for the skin of the eyelid, face, neck, and scalp, but may arise on any cutaneous site.. Extraorbital sites overall account for only approximately 25% of SCl, and the head and neck region is involved in 70% of cases. Involvement of the oral cavity in SC is rare. Hereby we present a case of cutaneous SC with direct extension and involvement of the oral mucosa.

Case presentation

A 25-year-old male presented with a painless ulcerated lesion on the left commissure area persisting for a duration of 3 months. The past medical history was unremarkable. Extra-oral examination showed a markedly ulcerated, exophytic, irregularly shaped mass of the left commissure extending to the labial and buccal mucosa. The lesion straddled the point of transition between mucosa and skin. The clinical differential diagnosis included squamous cell carcinoma, basal cell carcinoma, and salivary gland malignancy. On histopathological examination, a poorly differentiated malignant epithelial neoplasm with sebaceous differentiation was identified. Upon immunohistochemical testing, the neoplastic cells were strongly reactive for AE1/3, EMA, and CD15. In addition, CAM 5.2 and Ber-EP4 were also focally positive toward the periphery of the neoplastic islands. SOX10 was negative. The final diagnosis of sebaceous carcinoma was rendered. The patient was referred for oncologic treatment but lost to follow-up.

Conclusion

This case illustrates a rare case of SC with extension beyond its typical cutaneous boundaries into the oral mucosa. The presentation of SC in this manner underscores the complexity of diagnosing and managing such uncommon manifestations of skin cancers. This case reinforces that SC should be included in the differential diagnosis of lesions involving both skin and oral cavity and careful evaluation of both histopathology as well as immunohistochemistry is essential for accurate diagnosis.

累及口腔的皮脂腺癌:罕见病例报告
导言Sebaceous 癌(SC)是一种侵袭性的罕见皮肤恶性肿瘤。它明显偏爱眼睑、面部、颈部和头皮的皮肤,但也可能发生在任何皮肤部位。总体而言,眶外部位仅占鳞状上皮癌的 25%左右,而头颈部则占 70%。口腔受累的 SC 很少见。在此,我们介绍一例皮肤 SC 直接扩展并累及口腔黏膜的病例。病例介绍一名 25 岁的男性患者因左侧会厌部位的无痛性溃疡病变就诊,病程持续 3 个月。既往病史无异常。口腔外检查显示,左侧齿颊部有一个明显溃疡、外生性、形状不规则的肿块,一直延伸到唇部和口腔粘膜。病变横跨粘膜和皮肤之间的过渡点。临床鉴别诊断包括鳞状细胞癌、基底细胞癌和唾液腺恶性肿瘤。组织病理学检查发现,这是一种皮脂腺分化不良的恶性上皮肿瘤。经免疫组化检测,肿瘤细胞对 AE1/3、EMA 和 CD15 呈强反应性。此外,CAM 5.2 和 Ber-EP4 在肿瘤岛的外围也呈局部阳性。SOX10 呈阴性。最终诊断为皮脂腺癌。本病例是一个罕见的皮脂腺囊肿扩展到口腔粘膜的病例。以这种方式出现的 SC 强调了诊断和处理这种不常见皮肤癌表现的复杂性。本病例进一步说明,SC 应被纳入皮肤和口腔病变的鉴别诊断中,仔细评估组织病理学和免疫组化对准确诊断至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信