Benign Myoepithelial Neoplasms of Salivary Glands, Clinicopathologic Features and Review of the Literature

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-07-13 DOI:10.1016/j.oooo.2024.04.020

Mr. Christopher Hollingsworth, Dr. Rafik Abdelsayed, Dr. Mohammed Bindakhil

{"title":"Benign Myoepithelial Neoplasms of Salivary Glands, Clinicopathologic Features and Review of the Literature","authors":"Mr. Christopher Hollingsworth, Dr. Rafik Abdelsayed, Dr. Mohammed Bindakhil","doi":"10.1016/j.oooo.2024.04.020","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Myoepitheliomas (ME) are rare, benign neoplasms composed of myoepithelial cells with a highly variable histologic presentation profile; recognized subtypes include spindle, plasmacytoid/hyaline, epithelioid, and clear. This article presents the largest single-center case series with regards to this neoplasm class. Cases were analyzed with emphasis placed on relevant histological presentation, clinical appearance, and demographics. A 15-year literature review is included as a point of comparison.</p></div><div><h3>Materials and Methods</h3><p>Institutional case series with accompanying 15-year, retrospective literature review.</p></div><div><h3>Results</h3><p>Institutional Case Series:</em> </strong>The retrospective search revealed 13 cases of myoepithelial salivary gland tumors—9 benign myoepitheliomas & 4 malignant myoepithelial tumors (included for comparison). Tumor morphology was analyzed—epithelioid pattern, 6 cases (4 benign, 2 malignant); spindle cell pattern, 6 cases (4 benign, 2 malignant); plasmacytoid pattern, 7 cases (6 benign, 1 malignant). The characteristics of connective tissue stroma were also analyzed. The stroma was myxoid in 2 cases (1 benign, 1 malignant), fibrous in 5 cases (4 benign, 1 malignant), and necrotic in 2 cases (2 malignant). The difference in reported clinicopathologic characteristics was not statistically significant, except for the presence of mitosis (p=0.001).</p></div><div><h3>Literature Review</h3><p>The search revealed 139 records. 32 articles including 34 cases were included. Cell morphology and stromal features were analyzed. The pattern of tumor cells included—epithelioid, 9 cases (29%); spindle cell, 13 cases (41%); plasmacytoid, 14 cases (45%). The stroma was myxoid in 11 cases (40%), fibrinous in 9 cases (33.3%), and necrotic in 2 (7.4%) cases.</p></div><div><h3>Conclusions</h3><p>Rare salivary gland tumors, especially those arising in atypical locations with ambiguous morphological patterns, present a unique diagnostic challenge. Due to myoepithelioma's ability to manifest in the various glandular structures of the head and neck, dental professionals and physicians who encounter head and neck pathology must recognize this entity as part of their differential diagnosis when clinically appropriate</p></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 2","pages":"Page e34"},"PeriodicalIF":2.0000,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212440324001974","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

Myoepitheliomas (ME) are rare, benign neoplasms composed of myoepithelial cells with a highly variable histologic presentation profile; recognized subtypes include spindle, plasmacytoid/hyaline, epithelioid, and clear. This article presents the largest single-center case series with regards to this neoplasm class. Cases were analyzed with emphasis placed on relevant histological presentation, clinical appearance, and demographics. A 15-year literature review is included as a point of comparison.

Materials and Methods

Institutional case series with accompanying 15-year, retrospective literature review.

Results

Institutional Case Series:</em> </strong>The retrospective search revealed 13 cases of myoepithelial salivary gland tumors—9 benign myoepitheliomas & 4 malignant myoepithelial tumors (included for comparison). Tumor morphology was analyzed—epithelioid pattern, 6 cases (4 benign, 2 malignant); spindle cell pattern, 6 cases (4 benign, 2 malignant); plasmacytoid pattern, 7 cases (6 benign, 1 malignant). The characteristics of connective tissue stroma were also analyzed. The stroma was myxoid in 2 cases (1 benign, 1 malignant), fibrous in 5 cases (4 benign, 1 malignant), and necrotic in 2 cases (2 malignant). The difference in reported clinicopathologic characteristics was not statistically significant, except for the presence of mitosis (p=0.001).

Literature Review

The search revealed 139 records. 32 articles including 34 cases were included. Cell morphology and stromal features were analyzed. The pattern of tumor cells included—epithelioid, 9 cases (29%); spindle cell, 13 cases (41%); plasmacytoid, 14 cases (45%). The stroma was myxoid in 11 cases (40%), fibrinous in 9 cases (33.3%), and necrotic in 2 (7.4%) cases.

Conclusions

Rare salivary gland tumors, especially those arising in atypical locations with ambiguous morphological patterns, present a unique diagnostic challenge. Due to myoepithelioma's ability to manifest in the various glandular structures of the head and neck, dental professionals and physicians who encounter head and neck pathology must recognize this entity as part of their differential diagnosis when clinically appropriate

查看原文本刊更多论文

唾液腺良性肌上皮肿瘤、临床病理特征和文献综述

导言肌上皮瘤（ME）是一种罕见的良性肿瘤，由肌上皮细胞组成，组织学表现千变万化；公认的亚型包括纺锤型、浆液性/透明型、上皮样型和透明型。本文介绍了该类肿瘤最大的单中心病例系列。病例分析的重点是相关的组织学表现、临床表现和人口统计学特征。材料与方法机构病例系列，并附有 15 年的回顾性文献综述。结果机构病例系列：</em> </strong>回顾性检索发现了 13 例唾液腺肌上皮肿瘤--9 例良性肌上皮瘤& 4 例恶性肌上皮肿瘤（纳入比较）。对肿瘤形态进行了分析--上皮样型，6 例（4 例良性，2 例恶性）；纺锤形细胞型，6 例（4 例良性，2 例恶性）；浆细胞型，7 例（6 例良性，1 例恶性）。此外，还分析了结缔组织基质的特征。基质呈肌样的有 2 例（1 例良性，1 例恶性），纤维状的有 5 例（4 例良性，1 例恶性），坏死的有 2 例（2 例恶性）。除了有丝分裂（P=0.001）外，临床病理特征的报告差异无统计学意义。共纳入 32 篇文章，包括 34 个病例。对细胞形态和基质特征进行了分析。肿瘤细胞的形态包括：上皮样细胞，9 例（29%）；纺锤形细胞，13 例（41%）；浆细胞，14 例（45%）。结论罕见的唾液腺肿瘤，尤其是那些发生在不典型部位、形态模式模糊的肿瘤，给诊断带来了独特的挑战。由于肌上皮细胞瘤能在头颈部的各种腺体结构中表现出来，牙科专业人员和头颈部病理医生在临床上遇到这种肿瘤时必须将其作为鉴别诊断的一部分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.