The fertility outcome of assisted oocyte activation combined with spindle view-assisted intracytoplasmic sperm injection in patients with low fertilization rate

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-07-01 DOI:10.1016/j.tjog.2023.10.017

Wei-Che Lo , Chieh-Yu Lin , Chia-Jung Li , Chiung-Hui Hou , Lin-Hsuan Dai , Hsien-Ming Wu

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Abstract

Objective

To examine the possible synergic effect of spindle view-assisted intracytoplasmic sperm injection (SV-ICSI) with assisted oocyte activation (AOA) for low fertilization rate.

Materials and methods

A single-center retrospective study from 2019/09–2023/06, a total of 47 patients, autologous IVF cycle, and low fertilization rate history, including control group (SV-ICSI, 33 patients) and intervention group (AOA-SV-ICSI, 14 patients), comparing fertilization rate, blastocyst formation rate, and clinical pregnancy rate.

Results

The blastocyst formation rate was significantly higher (p = 0.020) in the AOA-SV-ICSI group than in the SV-ICSI group. The fertilization rate (P = 0.468) and clinical pregnancy rate (p = 0.057) were non-significant between groups.

Conclusion

The AOA-SV-ICSI group's blastocyst formation rate significantly improved in patients with previous low fertilization rates, which might help them obtain more useable embryos for further embryo implantation.

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辅助卵母细胞激活联合纺锤体视图辅助卵胞浆内单精子注射对低受精率患者的生育效果

目的探讨纺锤体视图辅助卵胞浆内单精子显微注射（SV-ICSI）与辅助卵母细胞活化（AOA）对低受精率可能产生的协同作用。材料与方法2019/09-2023/06单中心回顾性研究，共47例患者，自体IVF周期，低受精率病史，包括对照组（SV-ICSI，33例）和干预组（AOA-SV-ICSI，14例），比较受精率、囊胚形成率和临床妊娠率结果AOA-SV-ICSI组囊胚形成率显著高于SV-ICSI组（P = 0.020）。结论AOA-SV-ICSI 组的囊胚形成率明显高于 SV-ICSI 组，这可能有助于他们获得更多可用胚胎，以进一步进行胚胎植入。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464