Evolution of Natural Myocardial Shear Wave Behavior in Young Hearts: Determinant Factors and Reproducibility Analysis

IF 5.4 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of the American Society of Echocardiography Pub Date : 2024-11-01 DOI:10.1016/j.echo.2024.07.004

Ahmed S. Youssef MD , Aniela Petrescu MD, PhD , Thomas Salaets MD , Stéphanie Bézy MSc, PhD , Laurine Wouters MSc , Marta Orlowska MSc, PhD , Annette Caenen MSc, PhD , Jürgen Duchenne MSc, PhD , Alexis Puvrez MD , Bjorn Cools MD, PhD , Ruth Heying MD, PhD , Jan D’hooge MSc, PhD , Marc Gewillig MD, PhD , Jens-Uwe Voigt MD, PhD

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引用次数: 0

Abstract

Background

Myocardial diastolic function assessment in children by conventional echocardiography is challenging. High–frame rate echocardiography facilitates the assessment of myocardial stiffness, a key factor in diastolic function, by measuring the propagation velocities of myocardial shear waves (SWs). However, normal values of natural SWs in children are currently lacking. The aim of this study was to explore the behavior of natural SWs among children and adolescents, their reproducibility, and the factors affecting SW velocities from childhood into adulthood.

Methods

One hundred six healthy children (2-18 years of age) and 62 adults (19-80 years of age) were recruited. High–frame rate images were acquired using a modified commercial scanner. An anatomic M-mode line was drawn along the ventricular septum, and propagation velocities of natural SWs after mitral valve closure were measured in the tissue acceleration–coded M-mode display.

Results

Throughout life, SW velocities after mitral valve closure exhibited pronounced age dependency (r = 0.73; P < .001). Among the pediatric population, SW velocities correlated significantly with measures of cardiac geometry (septal thickness and left ventricular end-diastolic dimension), local hemodynamics (systolic blood pressure), and echocardiographic parameters of systolic and diastolic function (global longitudinal strain, mitral E/e′ ratio, isovolumic relaxation time, and mitral deceleration time) (P < .001). In a multivariate analysis including all these factors, the predictors of SW velocities were age, mitral E/e′, and global longitudinal strain (r = 0.81).

Conclusions

Natural myocardial SW velocities in children can be detected and measured. SW velocities showed significant dependence on age and diastolic function. Natural SWs could be a promising additive tool for the assessment of diastolic function among children.

查看原文本刊更多论文

年轻心脏自然心肌剪切波行为的演变：决定因素和重现性分析。

背景：用传统超声心动图评估儿童心肌舒张功能具有挑战性。最新的高帧频（HFR）超声心动图通过测量心肌剪切波（SW）的传播速度，有助于评估心肌僵硬度（MS）--舒张功能的一个关键因素。然而，目前尚缺乏儿童自然剪切波的正常值：方法：招募 106 名健康儿童（2-18 岁）和 62 名成人（19-80 岁）。使用改良的商用扫描仪采集 HFR 图像。沿室间隔绘制解剖 M 型，在组织加速度编码 M 型显示中测量二尖瓣关闭 (MVC) 后自然 SW 的传播速度：结果：在整个生命过程中，二尖瓣关闭不全后的SW速度表现出明显的年龄依赖性（r= 0.73；PC结论：可以检测和测量儿童的自然心肌SW速度。SW速度与年龄和舒张功能有明显的相关性。天然 SW 可作为评估儿童舒张功能的一种有前途的附加工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Society of Echocardiography 医学-心血管系统

CiteScore

9.50

自引率

12.30%

发文量

257

审稿时长

66 days

期刊介绍： The Journal of the American Society of Echocardiography(JASE) brings physicians and sonographers peer-reviewed original investigations and state-of-the-art review articles that cover conventional clinical applications of cardiovascular ultrasound, as well as newer techniques with emerging clinical applications. These include three-dimensional echocardiography, strain and strain rate methods for evaluating cardiac mechanics and interventional applications.