Buprenorphine vs. morphine: impact on neonatal opioid withdrawal syndrome (NOWS) outcomes in a single center retrospective study.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-04-01 Epub Date: 2024-07-13 DOI:10.1038/s41372-024-02046-7

Saminathan Anbalagan, Victoria Anderson, Michael T Favara, Daniela Stark, David Carola, Kolawole Solarin, Susan Adeniyi-Jones, Walter K Kraft, Zubair H Aghai

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引用次数: 0

Abstract

Objectives: To compare clinical outcomes for infants with neonatal opioid withdrawal syndrome (NOWS) treated with buprenorphine or morphine.

Study design: Retrospective study of infants born ≥35 weeks' gestation and admitted to the NICU for NOWS treatment between 2011 and 2022. Length of treatment, length of stay in the hospital, and the need for secondary medications were compared between buprenorphine and morphine treated neonates. Multiple regression analysis was performed, adjusting for baseline differences and confounders.

Results: 417 neonates were treated with morphine and 232 with buprenorphine. The buprenorphine group had shorter treatment days [-10.8 days; 95% CI: -8.08 to -13.53] and shorter hospital stay [-11.8 days; 95% CI: -8.83 to -14.78]. The buprenorphine group was no more likely to receive phenobarbital or clonidine (26% vs. 29%).

Conclusion: In this large single-center study, buprenorphine was associated with shorter lengths of treatment and hospital stay in the treatment of NOWS compared to morphine.

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丁丙诺啡与吗啡：单中心回顾性研究对新生儿阿片类药物戒断综合征（NOWS）结果的影响。

研究目的比较接受丁丙诺啡或吗啡治疗的新生儿阿片类药物戒断综合征（NOWS）患儿的临床疗效：研究设计：对 2011 年至 2022 年间妊娠期≥35 周、入住新生儿重症监护室接受 NOWS 治疗的婴儿进行回顾性研究。比较了丁丙诺啡和吗啡治疗新生儿的治疗时间、住院时间和对辅助药物的需求。在对基线差异和混杂因素进行调整后，进行了多元回归分析：结果：417 名新生儿接受了吗啡治疗，232 名接受了丁丙诺啡治疗。丁丙诺啡组的治疗天数更短[-10.8天；95% CI：-8.08至-13.53]，住院时间更短[-11.8天；95% CI：-8.83至-14.78]。丁丙诺啡组接受苯巴比妥或氯尼替丁（26% 对 29%）治疗的可能性不大：在这项大型单中心研究中，与吗啡相比，丁丙诺啡治疗 NOWS 的治疗时间和住院时间更短。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.