Association between Branched-Chain amino acids and Epilepsy: A Mendelian randomized study

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Chao Zhang , Lu Li , Wenping Li , Jia Fu , Lei Wu , Linlin Sun , Lifen Yao
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引用次数: 0

Abstract

Background

Branched-chain amino acids (BCAAs) have been affected epilepsy, yet conclusions remain inconclusive, lacking causal evidence regarding whether BCAAs affect epilepsy. Systematic exploration of the causal relationship between BCAAs and epilepsy could hand out new ideas for the treatment of epilepsy.

Methods

Utilizing bidirectional Mendelian randomization (MR) study, we investigated the causal relationship between BCAA levels and epilepsy. BCAA levels from genome-wide association studies (GWAS), including total BCAAs, leucine levels, isoleucine levels, and valine levels, were employed. Causal relationships were explored applying the method of inverse variance-weighted (IVW) and MR-Egger, followed by sensitivity analyses of the results to evaluate heterogeneity and pleiotropy.

Results

Through strict genetic variant selection, we find some related SNPs, total BCAA levels (9), leucine levels (11), isoleucine levels (7), and valine levels (6) as instrumental variables for our MR analysis. Following IVW and sensitivity analysis, total BCAAs levels (OR = 1.14, 95 % CI = 1.019 ∼ 1.285, P = 0.022) and leucine levels (OR = 1.15, 95 % CI = 1.018 ∼ 1.304, P = 0.025) had significant correlation with epilepsy.

Conclusions

There exists a causal relationship between the levels of total BCAAs and leucine with epilepsy, offering the new ideas into epilepsy potential mechanisms, holding significant implications for its prevention and treatment.

支链氨基酸与癫痫之间的关系:孟德尔随机研究
背景:支链氨基酸(BCAAs)对癫痫有影响,但结论仍不确定,缺乏BCAAs是否影响癫痫的因果证据。对 BCAAs 与癫痫之间的因果关系进行系统性探索,可为癫痫治疗提供新思路:利用双向孟德尔随机化(MR)研究,我们调查了 BCAA 水平与癫痫之间的因果关系。我们采用了全基因组关联研究(GWAS)中的 BCAA 水平,包括 BCAAs 总量、亮氨酸水平、异亮氨酸水平和缬氨酸水平。应用反方差加权(IVW)和MR-Egger方法探讨了因果关系,随后对结果进行了敏感性分析,以评估异质性和多义性:通过严格的遗传变异选择,我们找到了一些相关的 SNPs、BCAA 总含量(9 个)、亮氨酸含量(11 个)、异亮氨酸含量(7 个)和缬氨酸含量(6 个)作为 MR 分析的工具变量。经过IVW和敏感性分析,BCAAs总水平(OR = 1.14,95 % CI = 1.019 ∼ 1.285,P = 0.022)和亮氨酸水平(OR = 1.15,95 % CI = 1.018 ∼ 1.304,P = 0.025)与癫痫有显著相关性:总 BCAAs 和亮氨酸水平与癫痫之间存在因果关系,为癫痫的潜在机制提供了新思路,对癫痫的预防和治疗具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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