The Prevalence and Factors Associated with Coronary Heart Disease in Patients with Gout

IF 0.8 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
E. L. Markelova, M. S. Eliseev, E. V. Il’inykh, S. I. Glukhova,  E. L. Nasonov
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引用次数: 0

Abstract

Gout is associated with increased risk of cardiovascular disease (CVD) morbidity and mortality. Therefore, an association between coronary heart disease (CHD) and gout deserves careful examination.

. The aim of this study was to determine the prevalence of CHD and factors associated with CHD in patients (pts) with gout.

. The study involved 286 male patients with gout, age 51.2 [42.8; 59.4] years (ys), disease duration 6.2 [3.8; 12.1] ys. All patients underwent standard clinical examination screening traditional risk factors (TRFs) of CVDs. We estimated the adjusted odds ratio (OR) and 95% confidence interval (95% CI).

. CHD was found in 111 out of the 286 pts (38.8%), MI had a history in 29.7%. Compared to individuals with CHD, participants without CHD were older (56.7[52.1; 61.1] vs 46.2[40.6; 53.4] ys), had longer duration of gout (9.3[4.7; 15.1] vs 5.6[3.3; 9.7] ys) (for all p < 0.05). Abdominal obesity (OR, 3.6; 95% CI, 1.2–10.9), family history of CHD (OR, 2.2; 95% CI, 1.3–3.7), disease duration of gout more 10 ys (OR, 2.8; 95% CI, 1.6–4.7), age of gout onset < 35 ys (OR, 5.5; 95% CI, 2.6–11.7), intraosseous tophi (OR, 3.03; 95% CI, 1.8–5.01), nephrolithiasis (OR, 1.7; 95% CI, 1.04–3.04), renal failure (OR, 5.6; 95% CI, 2.7–11.4), serum total cholesterol (TC), (OR, 1.6; 95% CI, 1.0–2.8), serum creatinine (OR, 2.5; 95% CI, 1.2–5.1), increased the risk for CHD in patients with a gout.

. The prevalence of CHD was 38.8% among individuals with gout (one-third of patients had a history of MI 29.7%). Our study showed that both TRFs of CVD and the severity of gout and a history of renal failure contribute to the development of CHD in patients with gout.

Abstract Image

Abstract Image

痛风患者冠心病的患病率及相关因素
痛风会增加心血管疾病(CVD)的发病率和死亡率。因此,冠心病(CHD)与痛风之间的关联值得仔细研究。本研究旨在确定痛风患者(pts)中冠心病的患病率以及与冠心病相关的因素。研究涉及 286 名男性痛风患者,年龄 51.2 [42.8; 59.4] 岁,病程 6.2 [3.8; 12.1] 年。所有患者均接受了标准临床检查,筛查了心血管疾病的传统危险因素(TRFs)。我们估算了调整后的几率比(OR)和 95% 置信区间(95% CI)。286名患者中有111人(38.8%)患有冠心病,29.7%的患者有心肌梗死病史。与患有冠心病的患者相比,未患冠心病的患者年龄更大(56.7[52.1; 61.1] vs 46.2[40.6; 53.4]岁),痛风持续时间更长(9.3[4.7; 15.1] vs 5.6[3.3; 9.7]岁)(P均小于0.05)。01)、肾结石(OR,1.7;95% CI,1.04-3.04)、肾功能衰竭(OR,5.6;95% CI,2.7-11.4)、血清总胆固醇(TC)(OR,1.6;95% CI,1.0-2.8)、血清肌酐(OR,2.5;95% CI,1.2-5.1)会增加痛风患者罹患冠心病的风险。痛风患者的冠心病发病率为 38.8%(三分之一的患者有心肌梗死病史,占 29.7%)。我们的研究表明,心血管疾病的TRFs和痛风的严重程度以及肾功能衰竭史都会导致痛风患者罹患冠心病。
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来源期刊
Doklady Biochemistry and Biophysics
Doklady Biochemistry and Biophysics 生物-生化与分子生物学
CiteScore
1.60
自引率
12.50%
发文量
68
审稿时长
6-12 weeks
期刊介绍: Doklady Biochemistry and Biophysics is a journal consisting of English translations of articles published in Russian in biochemistry and biophysics sections of the Russian-language journal Doklady Akademii Nauk. The journal''s goal is to publish the most significant new research in biochemistry and biophysics carried out in Russia today or in collaboration with Russian authors. The journal accepts only articles in the Russian language that are submitted or recommended by acting Russian or foreign members of the Russian Academy of Sciences. The journal does not accept direct submissions in English.
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