Macromolecules from mushrooms, venoms, microorganisms, and plants for diabetes treatment - Progress or setback?

IF 3.3 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimie Pub Date : 2024-12-01 DOI:10.1016/j.biochi.2024.07.004

Asmaa Chbel , Ayoub Lafnoune , Imane Nait Irahal , Noureddine Bourhim

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Abstract

Diabetes is a substantial public health issue, while its prevalence continues to rise worldwide, affecting millions of persons between the ages of 20 and 80, the development of new therapeutic classes improving glycemic control and consequently micro and macrovascular complications are needed. Today, diabetes treatment is daily for life, and should not be interrupted. However, insulin secretagogues medications, and exogenous self-administration of insulin provide efficient antidiabetic effects, but their misuse leads to hypoglycemic complications besides other risks, hence the need to look for other natural products not to use solely but in concert with others types of medications. In this review, we will highlight briefly the pathophysiology of diabetes and its complications, then we will report the main bioactive macromolecules derived from various sources of natural products providing anti-diabetic properties. However, further researches need to be carried out to face the limitations hampering the development of effective natural drugs for diabetes treatment.

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从蘑菇、毒液、微生物和植物中提取用于治疗糖尿病的大分子--进步还是倒退？

糖尿病是一个重大的公共卫生问题，其发病率在全球范围内持续上升，影响着数百万 20 岁至 80 岁的人群，因此需要开发新的治疗手段来改善血糖控制，进而改善微血管和大血管并发症。如今，糖尿病治疗是终身性的，不应中断。然而，胰岛素促泌剂药物和外源性自给胰岛素具有高效的抗糖尿病作用，但滥用会导致低血糖并发症以及其他风险，因此需要寻找其他天然产品，而不是单独使用，而是与其他类型的药物协同使用。在这篇综述中，我们将简要介绍糖尿病及其并发症的病理生理学，然后报告从各种来源的天然产品中提取的具有抗糖尿病特性的主要生物活性大分子。然而，面对阻碍开发有效治疗糖尿病的天然药物的局限性，我们还需要开展进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimie 生物-生化与分子生物学

CiteScore

7.20

自引率

2.60%

发文量

219

审稿时长

40 days

期刊介绍： Biochimie publishes original research articles, short communications, review articles, graphical reviews, mini-reviews, and hypotheses in the broad areas of biology, including biochemistry, enzymology, molecular and cell biology, metabolic regulation, genetics, immunology, microbiology, structural biology, genomics, proteomics, and molecular mechanisms of disease. Biochimie publishes exclusively in English. Articles are subject to peer review, and must satisfy the requirements of originality, high scientific integrity and general interest to a broad range of readers. Submissions that are judged to be of sound scientific and technical quality but do not fully satisfy the requirements for publication in Biochimie may benefit from a transfer service to a more suitable journal within the same subject area.