Luc Souilla, Sophie Guillaumont, Annie Auer, Gael Metzler, Anne Requirand, Marie Vincenti, Gregoire De La Villeon, Jean-Luc Pasquie, Denis Mottet, Pascal Amedro
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引用次数: 0
Abstract
Background: To assess the feasibility, acceptability, safety, and short-term benefits of a tailored cardiac rehabilitation program for children and adolescents with long QT syndrome (LQTS).
Methods: Eight participants, aged between 6 and 18, with a positive LQTS genotype and impaired cardiorespiratory fitness, were enrolled in a 12-week centre-based cardiac rehabilitation program. The program included supervised exercise training group sessions (aerobic, resistance, and outdoor activities) and patient education workshops. Feasibility, acceptability, and safety of the program were prospectively monitored. Feedback from the parents, children, and professionals involved was collected from qualitative interviews. Short-term effects on cardiorespiratory fitness, muscle fitness, physical activity, and health-related quality of life (HRQoL) were measured between baseline and the end of the program.
Results: Retention (88% with one participant dropping out) and adherence (79%) rates were good, and no cardiac events occurred during the 12-week intervention period. Participants, parents, and healthcare professionals expressed a high level of satisfaction with the program. A significant increase between the beginning and the end of the program was observed for ventilatory anaerobic threshold (21.7±5.2 vs. 28.7±5.1 mL/kg/min, P=0.01, effect size=0.89), grip strength, (18±5.3 Kg vs. 20±4.7 Kg, P=0.02, effect size=0.90), lower limb explosive strength (142±36.5 cm vs. 148±24 cm, P=0.02, effect size=0.90), and parent-reported physical health dimension of HRQoL (65.6±9.75 vs. 84.4±20.35, P=0.03, effect size=0.87).
Conclusions: A 12-week tailored centre-based cardiac rehabilitation program was feasible, acceptable, and safe for children with LQTS. Cardiac rehabilitation for children with LQTS presents a new approach aligned with secondary prevention in youth with cardiac diseases.
Trial registration: The trial was registered at Clinicaltrials.gov (NCT05964322, registration date: 27/07/2023).
背景：评估为长 QT 综合征（LQTS）儿童和青少年量身定制的心脏康复计划的可行性、可接受性、安全性和短期效益：目的：评估为患有长 QT 综合征（LQTS）的儿童和青少年量身定制的心脏康复计划的可行性、可接受性、安全性和短期效益：8名年龄在6至18岁之间、LQTS基因型呈阳性且心肺功能受损的参与者参加了为期12周的中心心脏康复计划。该计划包括有监督的运动训练小组课程（有氧、阻力和户外活动）和患者教育研讨会。对该计划的可行性、可接受性和安全性进行了前瞻性监测。通过定性访谈收集了家长、儿童和相关专业人员的反馈意见。从基线到计划结束，对心肺功能、肌肉功能、体力活动和与健康相关的生活质量（HRQoL）的短期效果进行了测量：参加者的保留率（88%，其中一名参加者退出）和坚持率（79%）良好，在为期 12 周的干预期间未发生心脏事件。参与者、家长和医护人员对该计划表示高度满意。在计划开始和结束时，观察到通气无氧阈值（21.7±5.2 vs. 28.7±5.1毫升/千克/分钟，P=0.01，效应大小=0.89）、握力（18±5.3千克 vs. 20±4.7千克，P=0.02，效应大小=0.90）有明显提高。02，效应大小=0.90）、下肢爆发力（142±36.5 cm vs. 148±24 cm，P=0.02，效应大小=0.90）和家长报告的身体健康维度 HRQoL（65.6±9.75 vs. 84.4±20.35，P=0.03，效应大小=0.87）：对LQTS患儿来说，为期12周的定制中心心脏康复计划是可行的、可接受的和安全的。针对LQTS患儿的心脏康复治疗是一种符合青少年心脏疾病二级预防的新方法：该试验已在Clinicaltrials.gov网站注册（NCT05964322，注册日期：2023年7月27日）。
期刊介绍：
BMC Sports Science, Medicine and Rehabilitation is an open access, peer reviewed journal that considers articles on all aspects of sports medicine and the exercise sciences, including rehabilitation, traumatology, cardiology, physiology, and nutrition.
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