Testosterone and neurobehavioral outcomes in special operations forces military with multiple mild traumatic brain injury.

IF 1.7 4区医学 Q3 CLINICAL NEUROLOGY

NeuroRehabilitation Pub Date : 2024-01-01 DOI:10.3233/NRE-230291

Nathan Barnett, Milica Ljubic, Joyce Chung, Allison Capizzi

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Abstract

Background: U.S. Special Operations Forces (SOF) are at increased risk of multiple mild traumatic brain injury (mmTBI). Testosterone was prescribed for several participants in a VA program designed to address sequelae of mmTBI for SOF.

Objective: To determine testosterone prevalence in the Palo Alto VA Intensive Evaluation and Treatment Program (IETP) and observe for association between testosterone and neurobehavioral outcomes.

Methods: A retrospective cohort study included patients in the Palo Alto VA IETP. Sociodemographic data, testosterone blood levels, and neurobehavioral outcomes were collected from medical records.

Results: 55 IETP participants were included: six were testosterone users; the rest were classified as non-users. Testosterone use in this population is 11%, higher than reported national averages in the U.S. Of the 6 testosterone users, 2 (33%) had a formal diagnosis of hypogonadism prior to initiation of testosterone. Neurobehavioral outcome scores between testosterone users and non-users failed to show statistically significant differences, except for the PROMIS pain score, which was higher in the testosterone user population.

Conclusion: The current study did not find an association between mmTBI, testosterone use, or testosterone level and neurobehavioral outcomes. This study highlights a need to further examine the relationship between hypogonadism, mmTBI, SOF culture around testosterone, and the effects of testosterone use in this population.

查看原文本刊更多论文

睾酮与特种作战部队多发性轻微脑损伤军人的神经行为结果。

背景：美国特种作战部队（SOF）罹患多发性轻微脑损伤（mmTBI）的风险增加。在退伍军人事务部的一项旨在解决特种作战部队轻微脑损伤后遗症的计划中，为几名参与者开出了睾酮处方：确定帕洛阿尔托退伍军人强化评估和治疗计划（IETP）中睾酮的使用率，并观察睾酮与神经行为结果之间的关联：这项回顾性队列研究包括帕洛阿尔托退伍军人事务部 IETP 的患者。从医疗记录中收集社会人口学数据、睾酮血液水平和神经行为结果：结果：共纳入 55 名 IETP 参与者：其中 6 人使用睾酮，其余为非使用者。在 6 名睾酮使用者中，有 2 人（33%）在开始使用睾酮前已被正式诊断为性腺功能减退症。除了PROMIS疼痛评分在睾酮使用者中较高外，睾酮使用者和非使用者的神经行为结果评分在统计学上没有显著差异：目前的研究并未发现 mmTBI、睾酮使用或睾酮水平与神经行为结果之间存在关联。本研究强调，有必要进一步研究性腺功能减退症、mmTBI、围绕睾酮的 SOF 文化之间的关系，以及在该人群中使用睾酮的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroRehabilitation CLINICAL NEUROLOGY-REHABILITATION

CiteScore

3.20

自引率

0.00%

发文量

178

审稿时长

6-12 weeks

期刊介绍： NeuroRehabilitation, an international, interdisciplinary, peer-reviewed journal, publishes manuscripts focused on scientifically based, practical information relevant to all aspects of neurologic rehabilitation. We publish unsolicited papers detailing original work/research that covers the full life span and range of neurological disabilities including stroke, spinal cord injury, traumatic brain injury, neuromuscular disease and other neurological disorders. We also publish thematically organized issues that focus on specific clinical disorders, types of therapy and age groups. Proposals for thematic issues and suggestions for issue editors are welcomed.