Microbial etiology of vertebral osteomyelitis/discitis amid the opioid epidemic.

IF 2.9 2区医学 Q2 CLINICAL NEUROLOGY

Journal of neurosurgery. Spine Pub Date : 2024-07-12 Print Date: 2024-10-01 DOI:10.3171/2024.4.SPINE231071

S Alexander Ammerman, Alexander Keister, Joshua Vignolles-Jeong, Noah Mallory, David C Gibbs, Ryan G Eaton, Jianing Ma, David S Xu, Stephanus Viljoen, Andrew J Grossbach

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引用次数: 0

Abstract

Objective: The primary goal of this study was to establish the current microbial trends in vertebral osteomyelitis/discitis (VOD) amid the opioid epidemic and to determine if intravenous drug use (IVDU) predisposes one to a unique microbial profile of infection.

Methods: The authors performed a retrospective cohort study consisting of 1175 adult patients diagnosed with VOD between 2011 and 2022 at a single quaternary center. Data were acquired through retrospective chart review, with pertinent demographic and clinical information collected.

Results: Staphylococcus aureus was the most cultured organism in both the IVDU and non-IVDU groups at 56.1% and 40.7%, respectively. In the IVDU cohort, Serratia marcescens was the next most prevalently cultured organism at 13.9%.

Conclusions: The present study demonstrates that in the IVDU population S. marcescens is an organism of high concern. The potential for Serratia spp. infection should be accounted for when selecting empirical antimicrobial therapy in VOD patients.

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阿片类药物流行期间脊椎骨髓炎/椎间盘炎的微生物病因。

研究目的本研究的主要目的是在阿片类药物流行的背景下确定当前椎体骨髓炎/盘骨炎（VOD）的微生物趋势，并确定静脉注射毒品（IVDU）是否会导致独特的微生物感染特征：作者开展了一项回顾性队列研究，研究对象包括2011年至2022年期间在一家四级医疗中心确诊为VOD的1175名成年患者。数据通过回顾性病历获得，并收集了相关的人口统计学和临床信息：金黄色葡萄球菌是IVDU组和非IVDU组培养出最多的病原体，分别占56.1%和40.7%。在 IVDU 群体中，大肠沙雷氏菌是第二大培养菌，占 13.9%：本研究表明，在 IVDU 群体中，侯氏沙雷氏菌是一种值得高度关注的微生物。在为 VOD 患者选择经验性抗菌治疗时，应考虑到沙雷氏菌属感染的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of neurosurgery. Spine 医学-临床神经学

CiteScore

5.10

自引率

10.70%

发文量

396

审稿时长

6 months

期刊介绍： Primarily publish original works in neurosurgery but also include studies in clinical neurophysiology, organic neurology, ophthalmology, radiology, pathology, and molecular biology.