Diterpenoid alkaloids from Delphinium sherriffii.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-07-12 DOI:10.1080/10286020.2024.2376244

Guo-Qing Sun, Cheng-En Fu, Yang Yang, Xiao-Jian Li, Jia-Yi Ma, Shuai Huang, Xian-Li Zhou, Lin Chen

引用次数: 0

Abstract

Three new diterpenoid alkaloids (1, 2, 3) and seventeen known (4-20) compounds were isolated from the whole plant of Delphinium sherriffii Munz (Ranunculaceae). Their structures were elucidated by various spectroscopic analyses, including IR, HR-ESI-MS, 1D and 2D NMR spectra. All compounds were evaluated for the inhibitory activity of Sf9 cells and compound 5 exhibited the strongest cytotoxicity (IC₅₀ = 8.97 μM) against Sf9 cell line.

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Delphinium sherriffii 的二萜生物碱。

从 Delphinium sherriffii Munz（毛茛科）全株中分离出三个新的二萜生物碱（1、2、3）和 17 个已知化合物（4-20）。通过各种光谱分析，包括红外光谱、HR-ESI-MS、一维和二维核磁共振光谱，阐明了这些化合物的结构。评估了所有化合物对 Sf9 细胞的抑制活性，其中化合物 5 对 Sf9 细胞株的细胞毒性最强（IC50 = 8.97 μM）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.