Environmental–genetic interactions in ageing and dementia across Latin America

Abstract

Current dementia research has developed complex models of environmental–genetic interactions to better address multimodal disease phenotypes. New evidence highlights a stronger effect of social determinants of health than ancestry effects specific to Latin America and the Caribbean, which opens new agendas to address the diversity of these interactions in ageing and dementia. A new study on dementia prevalence in Latin America has found a stronger effect of social determinants of health than ancestry effects specific to this region, highlighting the need for interventions involving lifestyle changes, healthcare access and education.