Kun Shang , Chun Xu , Zheng Cao , Minhui Cui , Jianfei Sun , Haihua Xiao , Lingpu Zhang , Yibiao Wang , Hongbin Han
{"title":"Polymer-based delivery systems with metal complexes as contrast agents for medical imaging","authors":"Kun Shang , Chun Xu , Zheng Cao , Minhui Cui , Jianfei Sun , Haihua Xiao , Lingpu Zhang , Yibiao Wang , Hongbin Han","doi":"10.1016/j.ccr.2024.216071","DOIUrl":null,"url":null,"abstract":"<div><p>Medical contrast agents are indispensable for bioimaging in deep tissues, which significantly facilitate accurate clinical diagnoses. The forefront of current research focuses on the development of contrast agents with high contrast, low toxicity, and prolonger circulation half-life. Through combining different metal elements with polymer carriers, polymer-based delivery systems with metal complexes demonstrate low toxicity, versatility, and multifunctionality, which attract broad interest in medical imaging field. This review summarizes recent progress of using polymer-based delivery systems with metal complexes in magnetic resonance imaging (MRI), optical imaging (OI), computed tomography (CT), radiological imaging (RI), and other imaging applications.</p></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":null,"pages":null},"PeriodicalIF":20.3000,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Coordination Chemistry Reviews","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S001085452400417X","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
Medical contrast agents are indispensable for bioimaging in deep tissues, which significantly facilitate accurate clinical diagnoses. The forefront of current research focuses on the development of contrast agents with high contrast, low toxicity, and prolonger circulation half-life. Through combining different metal elements with polymer carriers, polymer-based delivery systems with metal complexes demonstrate low toxicity, versatility, and multifunctionality, which attract broad interest in medical imaging field. This review summarizes recent progress of using polymer-based delivery systems with metal complexes in magnetic resonance imaging (MRI), optical imaging (OI), computed tomography (CT), radiological imaging (RI), and other imaging applications.
期刊介绍：
Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers.
The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
