Barnacle inspired strategy combined with solvent exchange for enhancing wet adhesion of hydrogels to promote seawater-immersed wound healing

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2024-07-10 DOI:10.1016/j.bioactmat.2024.07.011

Guiyuan Zhao , Aijia Zhang , Xiangyan Chen , Guangli Xiang , Tianze Jiang , Xia Zhao

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引用次数: 0

Abstract

Hydrogels are promising materials for wound protection, but in wet, or underwater environments, the hydration layer and swelling of hydrogels can seriously reduce adhesion and limit their application. In this study, inspired by the structural characteristics of strong barnacle wet adhesion and combined with solvent exchange, a robust wet adhesive hydrogel (CP-Gel) based on chitosan and 2-phenoxyethyl acrylate was obtained by breaking the hydration layer and resisting swelling. As a result, CP-Gel exhibited strong wet adhesion to various interfaces even underwater, adapted to joint movement and skin twisting, resisted sustained rushing water, and sealed damaged organs. More importantly, on-demand detachment and controllable adhesion were achieved by promoting swelling. In addition, CP-Gel with good biosafety significantly promotes seawater-immersed wound healing and is promising for use in water-contact wound care, organ sealing, and marine emergency rescue.

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藤壶启发策略与溶剂交换相结合，增强水凝胶的湿粘附性，促进海水浸泡下的伤口愈合

水凝胶是一种很有前景的伤口保护材料，但在潮湿或水下环境中，水凝胶的水化层和膨胀会严重降低粘附性，限制其应用。本研究受藤壶湿粘附性强的结构特点启发，结合溶剂交换技术，通过打破水合层和抑制膨胀，获得了一种基于壳聚糖和 2-苯氧乙基丙烯酸酯的坚固湿粘附性水凝胶（CP-Gel）。因此，CP-凝胶即使在水下也能在各种界面上表现出很强的湿粘附性，能适应关节运动和皮肤扭曲，能抵御持续的水流冲刷，并能密封受损器官。更重要的是，通过促进溶胀，实现了按需剥离和可控粘附。此外，CP-凝胶具有良好的生物安全性，可显著促进海水浸泡伤口的愈合，有望用于水接触伤口护理、器官密封和海上紧急救援。

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.