Serosurvey of canine leishmaniasis in five departments near an identified human clinical case in Marseille (France)

IF 4.1 2区 医学 Q1 INFECTIOUS DISEASES
Younes Laidoudi , Jacques Sevestre , Samia Bedjaoui , Stéphanie Watier-Grillot , Bernard Davoust
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Abstract

Leishmania infantum is a protozoan parasite of the family Trypanosomatidae, transmitted by the bite of phlebotomine sand flies (Diptera: Psychodidae). It is responsible for human and canine leishmaniasis in countries bordering the Mediterranean basin. Here we describe a clinical case of human cutaneous leishmaniasis in a 76-year-old female patient living in Marseille. Upon interrogation, the patient had no history of recent travel or contact with animals. The study involved clinical, serological, and molecular investigation of the occurrence of Leishmania infection in 718 dogs from five departments within a 130 km radius perimeter around Marseille. Five dogs showed signs of moderate leishmaniasis. Additionally, the serological survey of dogs revealed a global seroprevalence of 5.1%, with a significantly different prevalence in the Vaucluse department. Molecular analysis and phylogenetic studies highlighted the close relatedness of Leishmania strains between human and canine hosts with 99.6% of identity, indicating local transmission. The findings underscore the importance of serological surveillance in dogs and human. In a One Health approach, it is necessary to continue investigating Leishmania infection in all potential reservoirs, especially for zoonotic L. infantum in wildlife (red foxes, leporids, rodents, etc.) but also in dogs, cats, and equids.

Abstract Image

在法国马赛发现的人类临床病例附近的五个省份进行犬利什曼病血清调查
婴儿利什曼原虫是一种原生动物寄生虫,属于锥虫科,通过嗜血沙蝇(双翅目:Psychodidae)叮咬传播。它是地中海盆地沿岸国家人类和犬类利什曼病的罪魁祸首。在此,我们描述了一名居住在马赛的 76 岁女性患者的皮肤利什曼病临床病例。经询问,患者近期没有旅行史或与动物接触史。该研究通过临床、血清学和分子学方法调查了马赛周围 130 公里半径范围内五个省 718 只狗的利什曼原虫感染情况。五只狗出现了中度利什曼病症状。此外,对狗进行的血清学调查显示,全球血清阳性率为 5.1%,沃克吕兹省的阳性率明显不同。分子分析和系统发育研究表明,人类和犬类宿主之间的利什曼病菌株亲缘关系密切,相似度高达 99.6%,这表明利什曼病在当地传播。这些发现强调了对狗和人类进行血清监测的重要性。在 "一个健康 "方法中,有必要继续调查所有潜在库中的利什曼原虫感染情况,特别是野生动物(红狐狸、leporids、啮齿动物等)中的人畜共患幼年利什曼原虫,以及狗、猫和马科动物中的利什曼原虫感染情况。
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来源期刊
One Health
One Health Medicine-Infectious Diseases
CiteScore
8.10
自引率
4.00%
发文量
95
审稿时长
18 weeks
期刊介绍: One Health - a Gold Open Access journal. The mission of One Health is to provide a platform for rapid communication of high quality scientific knowledge on inter- and intra-species pathogen transmission, bringing together leading experts in virology, bacteriology, parasitology, mycology, vectors and vector-borne diseases, tropical health, veterinary sciences, pathology, immunology, food safety, mathematical modelling, epidemiology, public health research and emergency preparedness. As a Gold Open Access journal, a fee is payable on acceptance of the paper. Please see the Guide for Authors for more information. Submissions to the following categories are welcome: Virology, Bacteriology, Parasitology, Mycology, Vectors and vector-borne diseases, Co-infections and co-morbidities, Disease spatial surveillance, Modelling, Tropical Health, Discovery, Ecosystem Health, Public Health.
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