Selective extraction of carnosic acid, carnosol, and rosmarinic acid from Rosmarinus officinalis L. using supercritical fluid and their antioxidant activity

IF 3.4 3区 工程技术 Q2 CHEMISTRY, PHYSICAL
Meryem Boufetacha , Abdelilah Ayad , Nicolas Thiebault , Nadia Boussetta , Elkhadir Gharibi , Mohammed Benali
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Abstract

Rosmarinus officinalis L. is one of the most widely exploited medicinal plants for its bioactive compounds, including rosmarinic acid (RA), carnosic acid (CA) and carnosol (CAR). This study aims to selectively extract these compounds, using supercritical fluids extraction with carbon dioxide and ethanol as co-solvents, based on the Hansen solubility parameters approach. This approach predicted that CA and CAR are highly soluble in the supercritical fluid. However, a weak interaction was predicted between RA and this fluid. The experimental findings indicated the highest amounts of RA and CA were observed at 150 bar and 80°C, resulting in yields of 3.43 mg/g dry weight (DW), and 18.9 mg/g DW, respectively. Favourable extraction conditions for CAR were recorded at 250 bar and 40°C, with a content of 19.1 mg/g DW. Evaluation of antioxidant activity using DPPH tests revealed that extracts obtained at 250 bar at 40 and 80°C rich in CAR have a stronger antioxidant power.

Abstract Image

利用超临界流体从迷迭香中选择性提取肉豆蔻酸、肉豆蔻醇和迷迭香酸及其抗氧化活性
迷迭香(Rosmarinus officinalis L.)是一种被广泛利用的药用植物,其生物活性化合物包括迷迭香酸(RAs)、肉毒碱(CA)和肉毒酚(CAR)。本研究以汉森溶解度参数法为基础,以二氧化碳和乙醇为助溶剂,采用超临界流体萃取法选择性地提取这些化合物。该方法预测 CA 和 CAR 在超临界流体中的溶解度很高。然而,根据预测,RA 与该流体之间的相互作用较弱。实验结果表明,在 150 巴和 80 摄氏度的条件下,RA 和 CA 的含量最高,产量分别为 3.43 毫克/克干重(DW)和 18.9 毫克/克干重。在 250 巴和 40 摄氏度的条件下,CAR 的提取效果较好,含量为 19.1 毫克/克干重。使用 DPPH 试验对抗氧化活性进行评估后发现,在 250 bar、40 和 80°C 条件下提取的富含 CAR 的提取物具有更强的抗氧化能力。
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来源期刊
Journal of Supercritical Fluids
Journal of Supercritical Fluids 工程技术-工程:化工
CiteScore
7.60
自引率
10.30%
发文量
236
审稿时长
56 days
期刊介绍: The Journal of Supercritical Fluids is an international journal devoted to the fundamental and applied aspects of supercritical fluids and processes. Its aim is to provide a focused platform for academic and industrial researchers to report their findings and to have ready access to the advances in this rapidly growing field. Its coverage is multidisciplinary and includes both basic and applied topics. Thermodynamics and phase equilibria, reaction kinetics and rate processes, thermal and transport properties, and all topics related to processing such as separations (extraction, fractionation, purification, chromatography) nucleation and impregnation are within the scope. Accounts of specific engineering applications such as those encountered in food, fuel, natural products, minerals, pharmaceuticals and polymer industries are included. Topics related to high pressure equipment design, analytical techniques, sensors, and process control methodologies are also within the scope of the journal.
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