Effects of attentional deployment training for relieving negative emotion in individuals with subthreshold depression

IF 3.7 3区 医学 Q1 CLINICAL NEUROLOGY
Shuyu Li , Shuang Li , Tao Ding , Sijia Liu , Xiuyan Guo , Zhiyuan Liu
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引用次数: 0

Abstract

Objective

As a prodromal stage to major depressive disorder (MDD), subthreshold depression (StD) has a higher prevalence in the population, resulting in a greater healthcare burden. StD individuals’ current negative emotion could be moderated by attentional deployment. However, it remains unclear whether attentional deployment training can mitigate subsequent negative emotion in StD individuals.

Methods

Based on 160 participants, we combined decision task (Experiment 1, N = 69), eye-tracking (Experiment 2, N = 40), and EEG (Experiment 3, N = 51) techniques to investigate how one-week attentional deployment (gain-focus, GF) training modulated the emotional processing of negative stimulus and its underlying neural correlates in StD individuals.

Results

After one-week GF training, StD individuals significantly reduced the first fixation time and total fixation time on the negative part (missed opportunities) of decision outcome and showed a decrease in emotional sensitivity to missed opportunities. An increase in N1 and decrease in P3 and LPP (late positive potentials) amplitudes, as well as a decrease in alpha oscillation, were observed when StD individuals faced missed opportunities after training. Additionally, the extent of reduction in StD individuals’ emotional sensitivity to missed opportunities could be significantly predicted by the degree of decrease in alpha oscillation.

Conclusion

One-week attentional deployment training could modulate negative emotion in StD individuals and the degree of change in alpha oscillation might act as an objective indicator for the effectiveness of training.

Significance

Our study provides a convenient and effective approach to alleviate the negative emotion of StD individuals.

注意力调配训练对缓解阈值下抑郁症患者负面情绪的影响
目的 作为重度抑郁障碍(MDD)的前驱阶段,阈下抑郁(StD)在人群中的发病率较高,造成了更大的医疗负担。阈下抑郁症患者当前的负面情绪可能会受到注意调配的调节。方法我们以160名参与者为基础,结合决策任务(实验1,69人)、眼动追踪(实验2,40人)和脑电图(实验3,51人)技术,研究了为期一周的注意力调配(增益-聚焦,GF)训练如何调节StD个体对负面刺激的情绪处理及其潜在的神经相关性。结果经过一周的 GF 训练后,StD 人在决策结果的负面部分(错失机会)上的首次固定时间和总固定时间明显减少,对错失机会的情绪敏感度也有所下降。训练后,当 StD 患者面对错过的机会时,他们的 N1 波幅增加,P3 和 LPP(晚期正电位)波幅减少,α 振荡也有所减少。结论为期一周的注意力调配训练可以调节 StD 患者的负面情绪,而阿尔法振荡的变化程度可以作为衡量训练效果的客观指标。
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来源期刊
Clinical Neurophysiology
Clinical Neurophysiology 医学-临床神经学
CiteScore
8.70
自引率
6.40%
发文量
932
审稿时长
59 days
期刊介绍: As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.
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