Role of histone deacetylases in neuroplasticity impairments and inflammation in major depression

Neuroscience Applied Pub Date : 2024-01-01 DOI:10.1016/j.nsa.2024.104081

A. Garayo-Larrea , A. Azqueta , R.M. Tordera

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Abstract

This paper critically reviews the interesting and extensive knowledge regarding the role of some HDACs in major depression. MD is associated with neuroplasticity failure and inflammatory events, in which, several histone deacetylase (HDACs) enzymes play a key role. Specifically, increased expression of specific HDACs are linked to depressive-like behaviour, repress the expression of the brain derived neurotrophic factor (BDNF), and induce a pro-inflammatory response. Conversely, other HDACs exert an antidepressant action, promote dendritic growth and protect neurons or immune cells from inflammatory events. The right balance between both types is needed to respond correctly to the different physiological/pathological stimuli. However, aberrant expressions or activities of specific HDACs could be associated with MD. Further studies should identify the mechanism by which MD regulates specific HDAC subtypes both in post-mortem brain tissue and in peripheral immune cells.

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组蛋白去乙酰化酶在重度抑郁症的神经可塑性损伤和炎症中的作用

本文对有关某些 HDACs 在重度抑郁症中的作用的有趣而广泛的知识进行了评论。重度抑郁症与神经可塑性衰竭和炎症事件有关，其中，几种组蛋白去乙酰化酶（HDACs）发挥着关键作用。具体来说，特定 HDACs 的表达增加与抑郁样行为有关，会抑制脑源性神经营养因子（BDNF）的表达，并诱发促炎反应。相反，其他 HDACs 则具有抗抑郁作用，促进树突生长，保护神经元或免疫细胞免受炎症事件的影响。要正确应对不同的生理/病理刺激，就必须在这两种类型之间取得适当的平衡。然而，特定 HDACs 的异常表达或活性可能与 MD 有关。进一步的研究应确定 MD 在死后脑组织和外周免疫细胞中调节特定 HDAC 亚型的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Neuroscience Applied

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