Treatment of severe hypertriglyceridemia through therapeutic plasma exchange in patients with acute pancreatitis or at risk of developing it.

IF 2.2 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Gastroenterologia y hepatologia Pub Date : 2024-07-09 DOI:10.1016/j.gastrohep.2024.502229

Eva Marín-Serrano, Ana Kerguelen Fuentes, Rubén Fernández-Martos, José Mostaza Prieto, Aurora Viejo Llorente, Ana Barbado Cano, Pedro Luis Martínez Hernández, María Dolores Martín-Arranz

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引用次数: 0

Abstract

Introduction and objectives: TPE drastically reduces serum triglyceride (sTG), but its role in the treatment of hypertriglyceridemia-induced acute pancreatitis (HTG-AP) or at risk of developing it, is not well established. The objectives were to assess the effectiveness and safety of TPE in the treatment of severe HTG (sHTG), as well as to evaluate the severity of HTG-AP treated with TPE.

Materials and methods: Observational-retrospective-single-center study, in which a descriptive analysis of sHTG treated with TPE was conducted, with the aim of treating HTG-AP or preventing its recurrence. TPE was performed if sTG≥ 1000 mg/dL after 24 hours of admission.

Results: 42 TPE were performed to treat 35 sHTG in 23 patients: 29 HTG-AP, and 6 sHTG with previous HTG-AP. Among the patients, 37% (13/55) were women, with 37 ± 14 years-old, 74.3% had normal BMI (25/35), 34% (12/35) were drinking > 40 g/alcohol/day and 54% (19/35) were diabetics. TPE significantly reduced the baseline sTG (4425 ± 2782 mg/dL vs. 709 ± 353 mg/dL, p < 0.001) in a single session, achieving a mean percentage reduction of 79 ± 13%; 20% (7/35) of sHTG cases required two TPE sessions to reduce sTG to < 1000 mg/dL. Adverse effects were reported in 4/42 TPE sessions (9,5%). sHTG-AP was observed in 3% of cases (1/29), and there were no deaths. sTG at 24 hours of admission showed no relation with the severity of APs.

Conclusion: The treatment of sHTG with TPE, with the aim of treating HTG-AP or preventing its recurrence, reduces sTG quickly and safety.

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通过治疗性血浆置换，治疗急性胰腺炎患者或有患急性胰腺炎风险的患者的严重高甘油三酯血症。

引言和目的：TPE可显著降低血清甘油三酯（sTG），但其在治疗高甘油三酯血症诱发的急性胰腺炎（HTG-AP）或有发生急性胰腺炎风险的患者中的作用尚未得到充分证实。研究目的是评估 TPE 治疗重度 HTG（sHTG）的有效性和安全性，并评估使用 TPE 治疗 HTG-AP 的严重程度：观察性-回顾性-单中心研究，对接受 TPE 治疗的 sHTG 进行描述性分析，目的是治疗 HTG-AP 或防止其复发。如果入院 24 小时后 sTG≥ 1000 mg/dL，则进行 TPE：结果：共进行了 42 次 TPE，治疗了 23 名患者中的 35 例 sHTG：结果：对 23 名患者中的 35 例高血压患者进行了 42 次 TPE 治疗，其中 29 例为 HTG-AP，6 例为既往接受过 HTG-AP 的高血压患者。患者中，37%（13/55）为女性，年龄为 37±14 岁，74.3%（25/35）体重指数正常，34%（12/35）饮酒量大于 40 克/天，54%（19/35）为糖尿病患者。TPE 明显降低了基线 sTG（4425±2782 mg/dL vs. 709±353 mg/dL, p结论：用 TPE 治疗 sHTG，旨在治疗 HTG-AP 或防止其复发，可快速、安全地降低 sTG。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastroenterologia y hepatologia GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

1.50

自引率

10.50%

发文量

147

审稿时长

48 days

期刊介绍： Gastroenterology and Hepatology is the first journal to cover the latest advances in pathology of the gastrointestinal tract, liver, pancreas, and bile ducts, making it an indispensable tool for gastroenterologists, hepatologists, internists and general practitioners.