The Risk of Infection-Caused Mortality in Gastric Adenocarcinoma: A Population-Based Study.

IF 1.4 Q4 GASTROENTEROLOGY & HEPATOLOGY
Gastroenterology Research Pub Date : 2024-06-01 Epub Date: 2024-06-29 DOI:10.14740/gr1715
Adnan Malik, Farman Ali, Muhammad Imran Malik, Shahbaz Qureshi
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引用次数: 0

Abstract

Background: Gastric adenocarcinoma (GAC) is a deadly tumor. Postoperative complications, including infections, worsen its prognosis and may affect overall survival. Little is known about perioperative complications as well as modifiable and non-modifiable risk factors. Early detection and treatment of these risk factors may affect overall survival and mortality.

Methods: We extracted GAC patient's data from the Surveillance, Epidemiology, and End Results (SEER) database and analyzed using Pearson's Chi-square, Cox regression, Kaplan-Meier, and binary regression methods in SPSS.

Results: At the time of analysis, 59,580 GAC patients were identified, of which 854 died of infection. Overall, mean survival in months was better for younger patients, age < 50 years vs. ≥ 50 years (60.45 vs. 56.75), and in females vs. males (65.23 vs. 53.24). The multivariate analysis showed that the risk of infectious mortality was higher in patients with age ≥ 50 years (hazard ratio (HR): 3.137; 95% confidence interval (CI): 2.178 - 4.517), not treated with chemotherapy (HR: 1.669; 95% CI: 1.356 - 2.056), or surgery (HR: 1.412; 95% CI:1.132 - 1.761) and unstaged patients (HR: 1.699; 95% CI: 1.278 - 2.258). In contrast, the mortality risk was lower in females (HR: 0.658; 95% CI: 0.561 - 0.773) and married patients (HR: 0.627; 95% CI: 0.506 - 0.778). The probability of infection was higher in older patients (odds ratio (OR) of 2.094 in ≥ 50 years), other races in comparison to Whites and Blacks (OR: 1.226), lesser curvature, not other specified (NOS) as a primary site (OR: 1.325), and patients not receiving chemotherapy (OR: 1.258).

Conclusion: Older, unmarried males with GAC who are not treated with chemotherapy or surgery are at a higher risk for infection-caused mortality and should be given special attention while receiving treatment.

胃腺癌感染致死风险:一项基于人群的研究
背景:胃腺癌(GAC)是一种致命的肿瘤:胃腺癌(GAC)是一种致命的肿瘤。包括感染在内的术后并发症会使预后恶化,并可能影响总生存率。人们对围手术期并发症以及可改变和不可改变的风险因素知之甚少。及早发现和治疗这些风险因素可能会影响总体生存率和死亡率:我们从监测、流行病学和最终结果(SEER)数据库中提取了GAC患者的数据,并使用SPSS中的Pearson's Chi-square、Cox回归、Kaplan-Meier和二元回归方法进行了分析:结果:在进行分析时,共发现了 59,580 名 GAC 患者,其中 854 人死于感染。总体而言,年龄小于 50 岁与年龄大于 50 岁(60.45 与 56.75)、女性与男性(65.23 与 53.24)的年轻患者的平均存活月数更高。多变量分析显示,年龄≥50岁(危险比(HR):3.137;95% 置信区间(CI):2.178 - 4.517)、未接受化疗(HR:1.669;95% CI:1.356 - 2.056)或手术(HR:1.412;95% CI:1.132 - 1.761)和未分期患者(HR:1.699;95% CI:1.278 - 2.258)的感染性死亡风险较高。相比之下,女性(HR:0.658;95% CI:0.561 - 0.773)和已婚患者(HR:0.627;95% CI:0.506 - 0.778)的死亡风险较低。年龄较大的患者(≥50 岁的几率比(OR)为 2.094)、其他种族患者(OR:1.226)、曲率较小、原发部位未注明(NOS)的患者(OR:1.325)和未接受化疗的患者(OR:1.258)的感染几率更高:结论:未接受化疗或手术治疗的老年未婚男性 GAC 患者因感染导致死亡的风险较高,在接受治疗时应给予特别关注。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Gastroenterology Research
Gastroenterology Research GASTROENTEROLOGY & HEPATOLOGY-
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