Prospective feasibility study of a novel rigidizing stabilizing overtube in the resection of complex gastrointestinal polyps.

IF 11.5 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Endoscopy Pub Date : 2025-01-01 Epub Date: 2024-07-11 DOI:10.1055/a-2350-4059

Salmaan Jawaid, Ahmed F Aboelezz, Gehad Daba, Mai Khalaf, Fares Ayoub, Noor Zabad, Michael Mercado, Tara Keihanian, Mohamed Othman

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引用次数: 0

Abstract

Background: A novel rigidizing overtube (ROT) was developed to facilitate endoscopic removal of complex gastrointestinal polyps. We aimed to prospectively evaluate the efficacy and safety of the device in the management of large gastrointestinal polyps.

Methods: A prospective, single-center study, conducted between May 2021 and April 2023, enrolled patients undergoing endoscopic resection of colon/duodenal polyps ≥25 mm. Primary outcomes were safety, technical success, and clinical success defined as the ability of ROT to facilitate endoscopic polyp removal without changing the initial resection method.

Results: 97 patients (98 polyps), with a mean polyp size of 33.2 mm (median 31.1), were evaluated. Technical and clinical success rates were 100% and 84%, respectively. Ileocecal valve location was the only predictor of clinical failure (P = 0.02). The mean time to reach the lesion was 7.2 minutes (95%CI 5-8), with overall resection and procedure times of 53.6 minutes (95%CI 48-61) and 88.9 minutes (95%CI 79-95), respectively. No device-related adverse events occurred. Lower technical (67%) and clinical (67%) success rates were seen for duodenal polyps (n = 6).

Conclusion: The novel ROT was safe, with high technical and clinical success during resection of complex colon polyps. Future studies will determine timing of implementation during routine endoscopic resection.

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在复杂胃肠道息肉切除术中使用新型硬质稳定套管的前瞻性可行性研究。

背景：为了便于内镜下切除复杂的胃肠道息肉，我们开发了一种新型硬化剂套管（ROT）。我们旨在前瞻性地评估该设备在治疗大型胃肠息肉方面的有效性和安全性：一项前瞻性单中心研究于 2021 年 5 月至 2023 年 4 月间进行，招募了接受结肠/十二指肠息肉≥25 毫米内镜切除术的患者。主要结果是安全性、技术成功率和临床成功率，临床成功率是指 ROT 在不改变初始切除方法的情况下促进内镜下息肉切除的能力：共评估了 97 名患者（98 个息肉），息肉平均大小为 33.2 毫米（中位数为 31.1）。技术和临床成功率分别为 100%和 84%。回盲瓣位置是临床失败的唯一预测因素（P = 0.02）。到达病灶的平均时间为 7.2 分钟（95%CI 5-8），总体切除和手术时间分别为 53.6 分钟（95%CI 48-61）和 88.9 分钟（95%CI 79-95）。没有发生与设备相关的不良事件。十二指肠息肉（n = 6）的技术成功率（67%）和临床成功率（67%）较低：结论：新型 ROT 很安全，在切除复杂结肠息肉时技术和临床成功率都很高。未来的研究将确定在常规内镜切除术中实施的时机。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endoscopy 医学-外科

CiteScore

5.80

自引率

11.80%

发文量

1401

审稿时长

2 months

期刊介绍： Endoscopy is a leading journal covering the latest technologies and global advancements in gastrointestinal endoscopy. With guidance from an international editorial board, it delivers high-quality content catering to the needs of endoscopists, surgeons, clinicians, and researchers worldwide. Publishing 12 issues each year, Endoscopy offers top-quality review articles, original contributions, prospective studies, surveys of diagnostic and therapeutic advances, and comprehensive coverage of key national and international meetings. Additionally, articles often include supplementary online video content.