Relationship between obesity and hypertrophic or dilated cardiomyopathy: The role of sex

IF 2.2 Q3 ENDOCRINOLOGY & METABOLISM

Clinical Obesity Pub Date : 2024-07-11 DOI:10.1111/cob.12692

Alexios S. Antonopoulos, Ioannis Panagiotopoulos, Dimitrios Terentes-Printzios, Mohamed Omer, Amgad Mentias, George Lazaros, Konstantinos Tsioufis, Islam Y. Elgendy, Charalambos Vlachopoulos

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引用次数: 0

Abstract

Evidence suggests an association between obesity and the risk for cardiomyopathy development; however, robust evidence is still lacking. In this study we sought to explore the relationship of obesity with hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) and possible interactions with sex using large-scale epidemiological real-world data. We analysed data from the Nationwide Inpatient Sample of US hospitalisations for the years 2015–2019. There were a total of 46 934 admissions with diagnosis of HCM and 170 924 with DCM. There was a significant interaction between cardiomyopathies' diagnosis with sex and age subgroups; the rates of both DCM and HCM increased with age (p < .001 for both); DCM diagnosis was significantly higher in males compared with females (0.85% vs. 0.35%, p < .001). After adjustment for age, sex, race and presence of arterial hypertension there was a significant stepwise positive association between obesity and the population rates of both cardiomyopathy subtypes. For hospitalised patients with a body mass index (BMI) ≥30 kg/m² there was an odds ratio (OR) of 1.68 (95% CI: 1.55–1.81, p < .001) for HCM and OR = 1.82 (95% CI: 1.79–1.84, p < .001) for DCM. More importantly, the positive relationship between a cardiomyopathy diagnosis (HCM or DCM) with increasing BMI was driven by the male sex (p < .001 for both) and it was non-significant in females. The findings from this nationwide observational analysis support a sexual dimorphism in the relationship between obesity and HCM or DCM, which should be further investigated.

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肥胖与肥厚型或扩张型心肌病的关系：性别的作用。

有证据表明，肥胖与心肌病发病风险之间存在关联；然而，目前仍缺乏有力的证据。在这项研究中，我们试图利用大规模流行病学真实世界数据，探讨肥胖与肥厚型心肌病（HCM）和扩张型心肌病（DCM）之间的关系，以及与性别之间可能存在的相互作用。我们分析了 2015-2019 年美国全国住院病人样本的数据。共有 46 934 人被诊断为 HCM，170 924 人被诊断为 DCM。心肌病诊断与性别和年龄亚组之间存在明显的交互作用；DCM 和 HCM 的发病率均随年龄的增长而增加（p 2）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Obesity ENDOCRINOLOGY & METABOLISM-

CiteScore

5.90

自引率

3.00%

发文量

期刊介绍： Clinical Obesity is an international peer-reviewed journal publishing high quality translational and clinical research papers and reviews focussing on obesity and its co-morbidities. Key areas of interest are: • Patient assessment, classification, diagnosis and prognosis • Drug treatments, clinical trials and supporting research • Bariatric surgery and follow-up issues • Surgical approaches to remove body fat • Pharmacological, dietary and behavioural approaches for weight loss • Clinical physiology • Clinically relevant epidemiology • Psychological aspects of obesity • Co-morbidities • Nursing and care of patients with obesity.