Determination of levodopa using a glassy carbon electrode modified with TiO2 nanoparticles and carbon nanotubes in real samples

IF 2.6 4区化学 Q3 ELECTROCHEMISTRY

Journal of Solid State Electrochemistry Pub Date : 2024-07-11 DOI:10.1007/s10008-024-05978-4

Fatemeh Ebrahimi, Amir Abbas Rafati, Ahmad Bagheri

{"title":"Determination of levodopa using a glassy carbon electrode modified with TiO2 nanoparticles and carbon nanotubes in real samples","authors":"Fatemeh Ebrahimi, Amir Abbas Rafati, Ahmad Bagheri","doi":"10.1007/s10008-024-05978-4","DOIUrl":null,"url":null,"abstract":"<div><p>This study presents a novel sensor for the detection of levodopa (LD) utilizing a glassy carbon electrode modified with a TiO<sub>2</sub>/MWCNT nanocomposite. Structural analysis confirmed the suitability of the nanocomposite for sensor fabrication, revealing enhancements in effective surface area and sensitivity. Characterization studies employing SEM, EDX, and FT-IR analyses provided insights into the composition and morphology of the modified electrode. The sensor exhibited exceptional performance metrics, including a wide linear detection range (19.6–545 µM), low detection limit (2.51 µM), high repeatability (78.1%), and remarkable average recovery rates in real samples (99.86%). Minimal interference from interfering species further demonstrated its practical utility. Moreover, the sensor’s direct applicability in diverse sample matrices, without the need for sample separation, highlighted its versatility and convenience. Comparative analysis revealed the sensor’s performance to be comparable to established methods, offering a cost-effective and streamlined approach to LD measurement. Overall, the modified glassy carbon electrode with TiO<sub>2</sub>/MWCNT nanocomposite presents a clear, suitable, and stable electrocatalytic response, promising significant advancements in biosensing technology for LD detection.</p></div>","PeriodicalId":665,"journal":{"name":"Journal of Solid State Electrochemistry","volume":"28 11","pages":"3985 - 3998"},"PeriodicalIF":2.6000,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Solid State Electrochemistry","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s10008-024-05978-4","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ELECTROCHEMISTRY","Score":null,"Total":0}

引用次数: 0

Abstract

This study presents a novel sensor for the detection of levodopa (LD) utilizing a glassy carbon electrode modified with a TiO₂/MWCNT nanocomposite. Structural analysis confirmed the suitability of the nanocomposite for sensor fabrication, revealing enhancements in effective surface area and sensitivity. Characterization studies employing SEM, EDX, and FT-IR analyses provided insights into the composition and morphology of the modified electrode. The sensor exhibited exceptional performance metrics, including a wide linear detection range (19.6–545 µM), low detection limit (2.51 µM), high repeatability (78.1%), and remarkable average recovery rates in real samples (99.86%). Minimal interference from interfering species further demonstrated its practical utility. Moreover, the sensor’s direct applicability in diverse sample matrices, without the need for sample separation, highlighted its versatility and convenience. Comparative analysis revealed the sensor’s performance to be comparable to established methods, offering a cost-effective and streamlined approach to LD measurement. Overall, the modified glassy carbon electrode with TiO₂/MWCNT nanocomposite presents a clear, suitable, and stable electrocatalytic response, promising significant advancements in biosensing technology for LD detection.

Abstract Image

查看原文本刊更多论文

在实际样品中使用经 TiO2 纳米粒子和碳纳米管修饰的玻璃碳电极测定左旋多巴

本研究介绍了一种新型左旋多巴（LD）检测传感器，该传感器采用了由 TiO2/MWCNT 纳米复合材料修饰的玻璃碳电极。结构分析证实了该纳米复合材料适用于传感器的制造，并揭示了其有效表面积和灵敏度的提高。利用 SEM、EDX 和 FT-IR 分析进行的表征研究深入揭示了改性电极的组成和形态。该传感器表现出卓越的性能指标，包括宽线性检测范围（19.6-545 µM）、低检测限（2.51 µM）、高重复性（78.1%）和实际样品中显著的平均回收率（99.86%）。干扰物的最小干扰进一步证明了它的实用性。此外，该传感器可直接应用于不同的样品基质，无需进行样品分离，突出了其多功能性和便利性。对比分析表明，该传感器的性能可与现有方法媲美，为 LD 测量提供了一种经济高效的简化方法。总之，含有 TiO2/MWCNT 纳米复合材料的改性玻璃碳电极具有清晰、合适和稳定的电催化反应，有望在 LD 检测的生物传感技术方面取得重大进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Solid State Electrochemistry 工程技术-电化学

CiteScore

4.80

自引率

4.00%

发文量

227

审稿时长

4.1 months

期刊介绍： The Journal of Solid State Electrochemistry is devoted to all aspects of solid-state chemistry and solid-state physics in electrochemistry. The Journal of Solid State Electrochemistry publishes papers on all aspects of electrochemistry of solid compounds, including experimental and theoretical, basic and applied work. It equally publishes papers on the thermodynamics and kinetics of electrochemical reactions if at least one actively participating phase is solid. Also of interest are articles on the transport of ions and electrons in solids whenever these processes are relevant to electrochemical reactions and on the use of solid-state electrochemical reactions in the analysis of solids and their surfaces. The journal covers solid-state electrochemistry and focusses on the following fields: mechanisms of solid-state electrochemical reactions, semiconductor electrochemistry, electrochemical batteries, accumulators and fuel cells, electrochemical mineral leaching, galvanic metal plating, electrochemical potential memory devices, solid-state electrochemical sensors, ion and electron transport in solid materials and polymers, electrocatalysis, photoelectrochemistry, corrosion of solid materials, solid-state electroanalysis, electrochemical machining of materials, electrochromism and electrochromic devices, new electrochemical solid-state synthesis. The Journal of Solid State Electrochemistry makes the professional in research and industry aware of this swift progress and its importance for future developments and success in the above-mentioned fields.