Biogenic synthesis of a nanocomposite based on gold nanoparticles and exfoliated graphite nanoplatelets as an electrocatalyst for methyldopa detection

IF 2.6 4区化学 Q3 ELECTROCHEMISTRY

Journal of Solid State Electrochemistry Pub Date : 2024-07-11 DOI:10.1007/s10008-024-05997-1

Milena Melo Vidi, Luan Gabriel Baumgarten, Eduardo Constante Martins, Edson Roberto Santana, Juliana Priscila Dreyer, João Paulo Winiarski, Iolanda Cruz Vieira

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Abstract

In this study, we report the development of an electrochemical sensor modified with exfoliated graphite nanoplatelets (xGnP) and gold nanoparticles (AuNP) synthesized using green grape plant extract (Vitis vinifera L.). The modified electrode, denoted as xGnP/AuNP-Grape/GCE, was successfully applied for the determination of methyldopa (MD) using square wave voltammetry (SWV). The characterization of the AuNP-Grape was performed using UV–Vis and ATR-FTIR spectroscopies, while transmission electron microscopy and X-ray diffraction were employed to analyze the xGnP-AuNP-Grape nanocomposite. The electrochemical properties of the modified electrodes were investigated using electrochemical impedance spectroscopy and cyclic voltammetry. AuNP-Grape/GCE and xGnP-AuNP-Grape/GCE exhibited a remarkable electrocatalytic effect of 250 mV towards MD compared to the bare glassy carbon electrode (GCE). In addition, notably, the utilization of xGnP-AuNP-Grape/GCE as the working electrode induced a change in the electrochemical behavior of MD from irreversible to reversible when compared to GCE. SWV was optimized with appropriate parameters, and a calibration plot for methyldopa was constructed within the concentration range of 0.082–14 µmol L^‒1. The obtained limits of detection and quantification were 0.024 and 0.082 µmol L^‒1, respectively. The proposed xGnP/AuNP-Grape/GCE electrochemical platform demonstrated excellent stability and sensitivity, offering a simple and rapid method for the quantification of methyldopa. The findings of this study contribute to the development of efficient electrochemical sensors for pharmaceutical and clinical analysis and demonstrate the versatility of using plant extract-mediated synthesis of AuNP in sensor applications.

Graphical Abstract

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生物合成基于金纳米颗粒和剥离石墨纳米片的纳米复合材料，作为检测甲基多巴的电催化剂

在本研究中，我们报告了用绿葡萄植物提取物（Vitis vinifera L.）合成的剥离石墨纳米片（xGnP）和金纳米颗粒（AuNP）修饰的电化学传感器的开发情况。改性后的电极被命名为 xGnP/AuNP-Grape/GCE, 成功地应用于方波伏安法（SWV）测定甲基多巴（MD）。利用紫外-可见光谱和 ATR-FTIR 光谱对 AuNP-Grape 进行了表征，同时利用透射电子显微镜和 X 射线衍射对 xGnP-AuNP-Grape 纳米复合材料进行了分析。使用电化学阻抗谱和循环伏安法研究了改性电极的电化学特性。与裸玻璃碳电极（GCE）相比，AuNP-Grape/GCE 和 xGnP-AuNP-Grape/GCE 对 MD 的电催化效果显著，达 250 mV。此外，值得注意的是，与 GCE 相比，使用 xGnP-AuNP-Grape/GCE 作为工作电极会导致 MD 的电化学行为从不可逆变为可逆。利用适当的参数对 SWV 进行了优化，并在 0.082-14 µmol L-1 的浓度范围内构建了甲基多巴的校准图。得到的检测限和定量限分别为 0.024 和 0.082 µmol L-1。所提出的 xGnP/AuNP-Grape/GCE 电化学平台表现出卓越的稳定性和灵敏度，为甲基多巴的定量提供了一种简单而快速的方法。本研究的发现有助于开发用于药物和临床分析的高效电化学传感器，并证明了在传感器应用中使用植物提取物介导合成 AuNP 的多功能性。

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来源期刊

Journal of Solid State Electrochemistry 工程技术-电化学

CiteScore

4.80

自引率

4.00%

发文量

227

审稿时长

4.1 months

期刊介绍： The Journal of Solid State Electrochemistry is devoted to all aspects of solid-state chemistry and solid-state physics in electrochemistry. The Journal of Solid State Electrochemistry publishes papers on all aspects of electrochemistry of solid compounds, including experimental and theoretical, basic and applied work. It equally publishes papers on the thermodynamics and kinetics of electrochemical reactions if at least one actively participating phase is solid. Also of interest are articles on the transport of ions and electrons in solids whenever these processes are relevant to electrochemical reactions and on the use of solid-state electrochemical reactions in the analysis of solids and their surfaces. The journal covers solid-state electrochemistry and focusses on the following fields: mechanisms of solid-state electrochemical reactions, semiconductor electrochemistry, electrochemical batteries, accumulators and fuel cells, electrochemical mineral leaching, galvanic metal plating, electrochemical potential memory devices, solid-state electrochemical sensors, ion and electron transport in solid materials and polymers, electrocatalysis, photoelectrochemistry, corrosion of solid materials, solid-state electroanalysis, electrochemical machining of materials, electrochromism and electrochromic devices, new electrochemical solid-state synthesis. The Journal of Solid State Electrochemistry makes the professional in research and industry aware of this swift progress and its importance for future developments and success in the above-mentioned fields.