Repeated exposure to multiple concurrent stressors alters visual processing in the adult posterior parietal cortex

IF 4.3 2区 医学 Q1 NEUROSCIENCES
Soo Bin Park, Gyorgy Lur
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Abstract

Chronic stress is well known to erode cognitive functions. Yet, our understanding of how repeated stress exposure impacts one of the fundamental bases of cognition: sensory processing, remains limited. The posterior parietal cortex (PPC) is a high order visual region, known for its role in visually guided decision making, multimodal integration, attention, and working memory. Here, we used functional measures to determine how repeated exposure to multiple concurrent stressors (RMS) affects sensory processing in the PPC in adult male mice. A longitudinal experimental design, repeatedly surveying the same population of neurons using in vivo two-photon imaging, revealed that RMS disrupts the balanced turnover of visually responsive cells in layer 2/3 of the PPC. Across the population, RMS-induced changes in visual responsiveness followed a bimodal distribution suggesting idiosyncratic stress effects. In cells that maintained their responsiveness across recording sessions, we found that stress reduced visual response magnitudes and feature selectivity. While we did not observe stress-induced elimination of excitatory synapses, noise correlation statistics indicated that RMS altered visual input to the neuronal population. The impact of RMS was restricted to visually evoked responses and was not evident in neuronal activity associated with locomotion onset. Together, our results indicate that despite no apparent synaptic reorganization, stress exposure in adulthood can disrupt sensory processing in the PPC, with the effects showing remarkable individual variation.

重复暴露于多种并发压力源会改变成人后顶叶皮层的视觉处理能力
众所周知,慢性压力会侵蚀认知功能。然而,我们对重复压力暴露如何影响认知的基本基础之一:感觉处理的了解仍然有限。后顶叶皮层(PPC)是一个高阶视觉区域,因其在视觉引导决策、多模态整合、注意力和工作记忆中的作用而闻名。在这里,我们使用功能测量方法来确定反复暴露于多种并发压力源(RMS)如何影响成年雄性小鼠顶叶后皮层的感觉处理。我们采用纵向实验设计,利用双光子成像技术对同一神经元群进行了反复调查,结果发现 RMS 会破坏 PPC 第 2/3 层视觉反应细胞的平衡更替。在整个群体中,RMS诱导的视觉反应性变化呈双峰分布,表明存在特异性应激效应。在记录过程中保持反应性的细胞中,我们发现应激降低了视觉反应幅度和特征选择性。虽然我们没有观察到应激诱导的兴奋性突触消失,但噪声相关统计表明,RMS 改变了神经元群的视觉输入。RMS 的影响仅限于视觉诱发反应,在与运动开始相关的神经元活动中并不明显。总之,我们的研究结果表明,尽管没有明显的突触重组,但成年期的压力暴露会扰乱PPC的感觉处理,其影响表现出显著的个体差异。
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来源期刊
Neurobiology of Stress
Neurobiology of Stress Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
9.40
自引率
4.00%
发文量
74
审稿时长
48 days
期刊介绍: Neurobiology of Stress is a multidisciplinary journal for the publication of original research and review articles on basic, translational and clinical research into stress and related disorders. It will focus on the impact of stress on the brain from cellular to behavioral functions and stress-related neuropsychiatric disorders (such as depression, trauma and anxiety). The translation of basic research findings into real-world applications will be a key aim of the journal. Basic, translational and clinical research on the following topics as they relate to stress will be covered: Molecular substrates and cell signaling, Genetics and epigenetics, Stress circuitry, Structural and physiological plasticity, Developmental Aspects, Laboratory models of stress, Neuroinflammation and pathology, Memory and Cognition, Motivational Processes, Fear and Anxiety, Stress-related neuropsychiatric disorders (including depression, PTSD, substance abuse), Neuropsychopharmacology.
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