V–Catalyzed Direct Ortho‐Aminomethylation of Phenols

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2024-10-01 DOI:10.1002/ajoc.202400194

引用次数: 0

Abstract

A strategy for cross‐dehydrogenative C(sp2)‐C(sp3) coupling was developed by direct and highly selective V‐catalyzed ortho‐aminomethylation of phenol with aniline derivatives. A series of aminomethylphenol compounds were obtained in moderate to good yields under mild reaction conditions and with a broad substrate scope. A possible radical mechanism was proposed, and it was found that the coordination of phenolic hydroxyl groups with V⁵⁺ was crucial for the effective activation of the ortho position.

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V 催化苯酚的直接正氨甲基化反应

通过苯酚与苯胺衍生物直接和高选择性的 V 催化邻氨基甲基化反应，开发了一种 C（sp2）-C（sp3）交叉脱氢偶联策略。在温和的反应条件下，获得了一系列氨甲基苯酚化合物，收率从中等到良好，底物范围广泛。研究人员提出了一种可能的自由基机理，并发现酚羟基与 V5+ 的配位是有效激活正位的关键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.