The relationship between follicle-stimulating hormone and metabolic dysfunction-associated fatty liver disease in men

IF 4.6 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nutrition & Diabetes Pub Date : 2024-07-11 DOI:10.1038/s41387-024-00314-1

Dong-Hua Bin, Fang Liu, Ke-Ping Peng, Min Zhan, Yan Tan, Qiao Liu, Wang Tang, Zeng-Nan Mo, Xiong-Jun Peng, Gui-Xiang Tian

{"title":"The relationship between follicle-stimulating hormone and metabolic dysfunction-associated fatty liver disease in men","authors":"Dong-Hua Bin, Fang Liu, Ke-Ping Peng, Min Zhan, Yan Tan, Qiao Liu, Wang Tang, Zeng-Nan Mo, Xiong-Jun Peng, Gui-Xiang Tian","doi":"10.1038/s41387-024-00314-1","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Objectives</h3><p>The present study aimed to investigate the relationship between male hormones and metabolic dysfunction-associated fatty liver disease (MAFLD) in males.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Data from the Fangchenggang Area Male Health and Examination Survey (FAMHES) were used to analyze the male hormone levels between MAFLD patients and controls. Univariate and multivariate logistic regression analyses were performed to identify risk factors for MAFLD. Receiver operating characteristic curve analysis was used to assess the diagnostic performance of male hormones for MAFLD.</p><h3 data-test=\"abstract-sub-heading\">Result</h3><p>A total of 1578 individuals were included, with 482 individuals (30.54%) of MAFLD, including 293 (18.57%) with mild disease and 189 (11.98%) with moderate-to-severe disease. The MAFLD patients were significantly older than those without MAFLD. The LH, FSH, and SHBG levels in the MAFLD patients were significantly greater than those in the control group. Age, FSH, LH, SHBG, and estradiol were all risk factors for MAFLD. Age, FSH, and LH were risk factors for moderate-to-severe MAFLD. FSH was an independent risk factor for MAFLD and moderate-to-severe MAFLD. FSH showed an excellent diagnostic value, with an AUC of 0.992 alone and 0.996 after adjusting age.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Our findings indicate that FSH may be a potential diagnostic and predictive biomarker for MAFLD.</p>","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition & Diabetes","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41387-024-00314-1","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives

The present study aimed to investigate the relationship between male hormones and metabolic dysfunction-associated fatty liver disease (MAFLD) in males.

Methods

Data from the Fangchenggang Area Male Health and Examination Survey (FAMHES) were used to analyze the male hormone levels between MAFLD patients and controls. Univariate and multivariate logistic regression analyses were performed to identify risk factors for MAFLD. Receiver operating characteristic curve analysis was used to assess the diagnostic performance of male hormones for MAFLD.

Result

A total of 1578 individuals were included, with 482 individuals (30.54%) of MAFLD, including 293 (18.57%) with mild disease and 189 (11.98%) with moderate-to-severe disease. The MAFLD patients were significantly older than those without MAFLD. The LH, FSH, and SHBG levels in the MAFLD patients were significantly greater than those in the control group. Age, FSH, LH, SHBG, and estradiol were all risk factors for MAFLD. Age, FSH, and LH were risk factors for moderate-to-severe MAFLD. FSH was an independent risk factor for MAFLD and moderate-to-severe MAFLD. FSH showed an excellent diagnostic value, with an AUC of 0.992 alone and 0.996 after adjusting age.

Conclusions

Our findings indicate that FSH may be a potential diagnostic and predictive biomarker for MAFLD.

Abstract Image

查看原文本刊更多论文

男性卵泡刺激素与代谢功能障碍相关脂肪肝之间的关系

方法采用防城港地区男性健康与体检调查（FAMHES）数据，分析MAFLD患者与对照组之间的雄性激素水平。进行单变量和多变量逻辑回归分析，以确定MAFLD的危险因素。结果共纳入 1578 人，其中 482 人（30.54%）患有 MAFLD，包括 293 例（18.57%）轻度 MAFLD 患者和 189 例（11.98%）中重度 MAFLD 患者。MAFLD患者的年龄明显大于非MAFLD患者。MAFLD患者的LH、FSH和SHBG水平明显高于对照组。年龄、FSH、LH、SHBG 和雌二醇都是 MAFLD 的危险因素。年龄、FSH和LH是中重度MAFLD的风险因素。FSH是MAFLD和中重度MAFLD的独立风险因素。我们的研究结果表明，FSH 可能是 MAFLD 的潜在诊断和预测生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nutrition & Diabetes ENDOCRINOLOGY & METABOLISM-NUTRITION & DIETETICS

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Nutrition & Diabetes is a peer-reviewed, online, open access journal bringing to the fore outstanding research in the areas of nutrition and chronic disease, including diabetes, from the molecular to the population level.