Association of Helicobacter pylori Infection with Depression and Anxiety: A Systematic Review and Meta-Analysis

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of Clinical Practice Pub Date : 2024-07-10 DOI:10.1155/2024/9247586

Lu Li, Yadi Ren, Zeyu Wang, Yanqing Niu, Ying Zhao, Xiaherezhati Aihaiti, Yinglan Ji, Man Li

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Abstract

Introduction. The association between Helicobacter pylori (H. pylori) infection and depression and anxiety has been reported in the literature. The aim of this meta-analysis is to investigate the association of H. pylori infection with depression and anxiety. Methods. A systematic search was conducted in PubMed, Web of Science, Embase, and Chinese databases for observational studies that reported the incidence or prevalence of depression and anxiety in patients with H. pylori infection. We conducted meta-analysis with a random-effects model. Results. A total of twelve studies were included in this meta-analysis. Significant and positive association was found for H. pylori infection with anxiety (OR 2.49, 95% CI 1.83–3.39), but not depression (OR 1.40, 95% CI 0.75–2.58). Subgroup analysis from study design noted a significant positive association between H. pylori infection and anxiety (case-control and cross-sectional study, OR 2.36, 95% CI 1.65–3.38; cohort study, RR 1.72, 95% CI 1.28–2.32). The similar trend among studies used the Self-Rating Anxiety Scale (OR 2.43, 95% CI 1.78–3.32) and other questionnaires (OR 2.41, 95% CI 1.50–3.87) have been observed. However, subgroup analysis of the association between H. pylori infection and depression yields different results. Subgroup analysis from cohort studies noted a significant association between H. pylori infection and depression (RR 1.99, 95% CI 1.33–2.99), but not case-control and cross-sectional studies (OR 1.20, 95% CI 0.59–2.46). A significant positive association has been observed among studies used the Self-Rating Depression Scale (OR 2.03, 95% CI 1.11–3.70), as opposed to studies using other questionnaires (OR 1.03, 95% CI 0.31–3.44). Conclusion. This meta-analysis provide the support that a significant positive association between H. pylori infection and anxiety disorders. However, the association between H. pylori infection and depression appears to be insignificant.

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幽门螺杆菌感染与抑郁和焦虑的关系：系统回顾与元分析

简介幽门螺杆菌（H. pylori）感染与抑郁和焦虑之间的关系已有文献报道。本荟萃分析旨在研究幽门螺杆菌感染与抑郁和焦虑之间的关系。研究方法我们在 PubMed、Web of Science、Embase 和中文数据库中对报道幽门螺杆菌感染患者抑郁和焦虑发生率或流行率的观察性研究进行了系统检索。我们采用随机效应模型进行了荟萃分析。结果本次荟萃分析共纳入了 12 项研究。研究发现，幽门螺杆菌感染与焦虑（OR 2.49，95% CI 1.83-3.39）有显著的正相关，但与抑郁（OR 1.40，95% CI 0.75-2.58）无显著相关。根据研究设计进行的分组分析表明，幽门螺杆菌感染与焦虑之间存在显著的正相关关系（病例对照和横断面研究，OR 2.36，95% CI 1.65-3.38；队列研究，RR 1.72，95% CI 1.28-2.32）。使用焦虑自评量表（OR 2.43，95% CI 1.78-3.32）和其他问卷（OR 2.41，95% CI 1.50-3.87）进行的研究也观察到类似的趋势。然而，对幽门螺杆菌感染与抑郁之间的关系进行的亚组分析却得出了不同的结果。对队列研究进行的亚组分析表明，幽门螺杆菌感染与抑郁之间存在显著关联（RR 1.99，95% CI 1.33-2.99），但病例对照和横断面研究（OR 1.20，95% CI 0.59-2.46）则未发现这种关联。使用抑郁自评量表的研究（OR 2.03，95% CI 1.11-3.70）与使用其他问卷的研究（OR 1.03，95% CI 0.31-3.44）相比，观察到了明显的正相关。结论这项荟萃分析支持幽门螺杆菌感染与焦虑症之间存在显著的正相关。然而，幽门螺杆菌感染与抑郁症之间的关系似乎并不显著。

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来源期刊

International Journal of Clinical Practice 医学-医学：内科

CiteScore

5.30

自引率

0.00%

发文量

274

审稿时长

3-8 weeks

期刊介绍： IJCP is a general medical journal. IJCP gives special priority to work that has international appeal. IJCP publishes: Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion] Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion] Study design and interpretation. Example. [Always peer reviewed] Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed] Meta-analyses. [Always peer reviewed] Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed] Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed] ''How to…'' papers. Example. [Always peer reviewed] Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed] Letters. [Peer reviewed at the editor''s discretion] International scope IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.