Mechanochemical synthesis of β-cyclodextrin urea derivatives under reactive CO2 atmosphere by Staudinger aza-Wittig reaction†

Sawssen Nasri, Maxime Lestoquoy, Anne Ponchel, Eric Monflier and Stéphane Menuel
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Abstract

Various ureido β-cyclodextrins can be easily synthesised by mechanochemistry from azido-β-cyclodextrins, carbon dioxide and amino derivatives. The reaction was carried out with short reaction times, without solvents and without thermal activation, greatly reducing the environmental impact of the synthesis.

Abstract Image

在活性 CO2 气氛下通过 Staudinger aza-Wittig 反应机械化学合成 β-环糊精脲衍生物†。
以叠氮-β-环糊精、二氧化碳和氨基衍生物为原料,通过机械化学反应可轻松合成各种脲基 β-环糊精。该反应无需溶剂和热活化,反应时间短,大大降低了合成对环境的影响。
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