Bright light therapy-induced improvements of mood, cognitive functions and cerebellar functional connectivity in subthreshold depression: A randomized controlled trial

IF 5.3 1区 心理学 Q1 PSYCHOLOGY, CLINICAL
Guanmao Chen , Zixuan Guo , Pan Chen , Zibin Yang , Hong Yan , Shilin Sun , Wenhao Ma , Yuan Zhang , Zhangzhang Qi , Wenjie Fang , Lijun Jiang , Qian Tao , Ying Wang
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引用次数: 0

Abstract

Background

The efficacy of bright light therapy (BLT) in ameliorating depression has been validated. The present study is to investigate the changes of depressive symptoms, cognitive function and cerebellar functional connectivity (FC) following BLT in individuals with subthreshold depression (StD).

Method

Participants were randomly assigned to BLT group (N = 47) or placebo (N = 41) in this randomized controlled trial between March 2020 and June 2022. Depression severity and cognitive function were assessed, as well as resting-state functional MRI scan was conducted before and after 8-weeks treatment. Seed-based whole-brain static FC (sFC) and dynamic FC (dFC) analyses of the bilateral cerebellar subfields were conducted. Besides, a multivariate regression model examined whether baseline brain FC was associated with changes of depression severity and cognitive function during BLT treatment.

Results

After 8-week BLT treatment, individuals with StD showed improved depressive symptoms and attention/vigilance cognitive function. BLT also increased sFC between the right cerebellar lobule IX and left temporal pole, and decreased sFC within the cerebellum, and dFC between the right cerebellar lobule IX and left medial prefrontal cortex. Moreover, the fusion of sFC and dFC at baseline could predict the improvement of attention/vigilance in response to BLT.

Conclusions

The current study identified that BLT improved depressive symptoms and attention/vigilance, as well as changed cerebellum-DMN connectivity, especially in the cerebellar-frontotemporal and cerebellar internal FC. In addition, the fusion features of sFC and dFC at pre-treatment could serve as an imaging biomarker for the improvement of attention/vigilance cognitive function after BLT in StD.

强光疗法可改善阈下抑郁症患者的情绪、认知功能和小脑功能连接:随机对照试验
背景亮光疗法(BLT)在改善抑郁症方面的疗效已得到验证。本研究旨在探讨阈下抑郁症(StD)患者接受亮光疗法后抑郁症状、认知功能和小脑功能连接(FC)的变化。评估抑郁严重程度和认知功能,并在8周治疗前后进行静息态功能磁共振成像扫描。对双侧小脑亚场进行了基于种子的全脑静态FC(sFC)和动态FC(dFC)分析。结果经过8周的BLT治疗后,StD患者的抑郁症状和注意力/警觉认知功能均有所改善。BLT还增加了右侧小脑第九小叶与左侧颞极之间的sFC,降低了小脑内的sFC和右侧小脑第九小叶与左侧内侧前额叶皮层之间的dFC。结论 目前的研究发现,BLT改善了抑郁症状和注意力/警觉性,并改变了小脑-DMN连通性,尤其是小脑-额颞叶和小脑内部FC。此外,治疗前sFC和dFC的融合特征可作为StD患者BLT治疗后注意力/警觉认知功能改善的影像生物标志物。
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来源期刊
CiteScore
10.70
自引率
5.70%
发文量
38
审稿时长
33 days
期刊介绍: The International Journal of Clinical and Health Psychology is dedicated to publishing manuscripts with a strong emphasis on both basic and applied research, encompassing experimental, clinical, and theoretical contributions that advance the fields of Clinical and Health Psychology. With a focus on four core domains—clinical psychology and psychotherapy, psychopathology, health psychology, and clinical neurosciences—the IJCHP seeks to provide a comprehensive platform for scholarly discourse and innovation. The journal accepts Original Articles (empirical studies) and Review Articles. Manuscripts submitted to IJCHP should be original and not previously published or under consideration elsewhere. All signing authors must unanimously agree on the submitted version of the manuscript. By submitting their work, authors agree to transfer their copyrights to the Journal for the duration of the editorial process.
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