Individual-based morphological brain network changes in children with Rolandic epilepsy

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2024-06-29 DOI:10.1016/j.clinph.2024.06.013

Yu Yin , Xiaofan Qiu , Lisha Nie , Fuqin Wang , Xinyu Luo , Chunfeng Zhao , Haoyue Yu , Dan Luo , Jinhui Wang , Heng Liu

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引用次数: 0

Abstract

Objective

To investigate the local cortical morphology and individual-based morphological brain networks (MBNs) changes in children with Rolandic epilepsy (RE).

Methods

Based on the structural MRI data of 56 children with RE and 56 healthy controls (HC), we constructed four types of individual-based MBNs using morphological indices (cortical thickness [CT], fractal dimension [FD], gyrification index [GI], and sulcal depth [SD]). The global and nodal properties of the brain networks were analyzed using graph theory. The between-group difference in local morphology and network topology was estimated, and partial correlation analysis was further analyzed.

Results

Compared with the HC, children with RE showed regional GI increases in the right posterior cingulate gyrus and SD increases in the right anterior cingulate gyrus and medial prefrontal cortex. Regarding the network level, RE exhibited increased characteristic path length in CT-based and FD-based networks, while decreased FD-based network node efficiency in the right inferior frontal gyrus. No significant correlation between altered morphological features and clinical variables was found in RE.

Conclusions

These findings indicated that children with RE have disrupted morphological brain network organization beyond local morphology changes.

Significance

The present study could provide more theoretical basis for exploring the neuropathological mechanisms in RE.

查看原文本刊更多论文

罗兰氏癫痫患儿基于个体的脑形态网络变化

方法基于56名RE患儿和56名健康对照组（HC）的结构磁共振成像数据，利用形态学指标（皮质厚度[CT]、分形维度[FD]、回旋化指数[GI]和沟深度[SD]）构建了四种基于个体的脑形态学网络（MBN）。利用图论分析了大脑网络的全局和节点特性。结果与HC相比，RE患儿右侧扣带回后部的GI增加，右侧扣带回前部和内侧前额叶皮层的SD增加。在网络水平上，RE 在基于 CT 和基于 FD 的网络中表现出特征路径长度增加，而在右侧额叶下回则表现出基于 FD 的网络节点效率降低。结论本研究结果表明，RE患儿除局部形态学改变外，还存在形态学脑网络组织破坏。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.