Antidiabetic and prebiotic activities of flavonoids from Cyperus conglomeratus rottb

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Systematics and Ecology Pub Date : 2024-07-09 DOI:10.1016/j.bse.2024.104867

Ahmed Ashour , Reham M. Samra , Mohamed Samir Darwish , Noha A. Abou-Zeid , Ahmed A. Zaki

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Abstract

One new flavan (1), besides four known flavanones (2–5), was isolated from the aerial parts of Cyperus conglomeratus Rottb. Their structures were established by spectroscopic methods including one and two-dimensional NMR and high-resolution MS. Their antidiabetic activity was evaluated by measuring the inhibitory effect on α-amylase, α-glucosidase, and glycogen phosphorylase. The prebiotic activity was assessed utilizing two probiotic Lacticaseibacillus strains. The effect of the compounds on the enzyme profile of the tested probiotic strains was also evaluated. The promising activity against the tested enzymes was shown by compounds 2 and 4. All compounds exhibited an enhancement in alkaline phosphatase activity in the enzyme profile of Lb. rhamnosus and Lb. paracasei. This study demonstrated that the isolated flavonoids could be used as dietary supplements or in the development of functional foods for diabetes and prebiotics.

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腐生香柏中黄酮类化合物的抗糖尿病和益生元活性

除了四种已知的黄烷酮（2-5）之外，还从砾叶香柏（Cyperus conglomeratus Rottb）的气生部分分离出一种新的黄烷（1）。通过光谱方法（包括一维和二维核磁共振以及高分辨率质谱）确定了它们的结构。通过测量对 α-淀粉酶、α-葡萄糖苷酶和糖原磷酸化酶的抑制作用，评估了它们的抗糖尿病活性。利用两株益生乳酸杆菌菌株对益生活性进行了评估。此外，还评估了这些化合物对受试益生菌株酶谱的影响。化合物 2 和 4 对测试酶具有良好的活性。在鼠李糖球菌和副酸杆菌的酶谱中，所有化合物都显示出对碱性磷酸酶活性的增强作用。这项研究表明，分离出的黄酮类化合物可用作膳食补充剂或开发糖尿病功能食品和益生元。

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来源期刊

Biochemical Systematics and Ecology 生物-进化生物学

CiteScore

3.00

自引率

12.50%

发文量

147

审稿时长

43 days

期刊介绍： Biochemical Systematics and Ecology is devoted to the publication of original papers and reviews, both submitted and invited, in two subject areas: I) the application of biochemistry to problems relating to systematic biology of organisms (biochemical systematics); II) the role of biochemistry in interactions between organisms or between an organism and its environment (biochemical ecology). In the Biochemical Systematics subject area, comparative studies of the distribution of (secondary) metabolites within a wider taxon (e.g. genus or family) are welcome. Comparative studies, encompassing multiple accessions of each of the taxa within their distribution are particularly encouraged. Welcome are also studies combining classical chemosystematic studies (such as comparative HPLC-MS or GC-MS investigations) with (macro-) molecular phylogenetic studies. Studies that involve the comparative use of compounds to help differentiate among species such as adulterants or substitutes that illustrate the applied use of chemosystematics are welcome. In contrast, studies solely employing macromolecular phylogenetic techniques (gene sequences, RAPD studies etc.) will be considered out of scope. Discouraged are manuscripts that report known or new compounds from a single source taxon without addressing a systematic hypothesis. Also considered out of scope are studies using outdated and hard to reproduce macromolecular techniques such as RAPDs in combination with standard chemosystematic techniques such as GC-FID and GC-MS.