Liposomal nano-carriers mediated targeting of liver disorders: mechanisms and applications.

IF 3.6 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-07-10 DOI:10.1080/08982104.2024.2377085

Mona M AbouSamra

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引用次数: 0

Abstract

Liver disorders present a significant global health challenge, necessitating the exploration of innovative treatment modalities. Liposomal nanocarriers have emerged as promising candidates for targeted drug delivery to the liver. This review offers a comprehensive examination of the mechanisms and applications of liposomal nanocarriers in addressing various liver disorders. Firstly discussing the liver disorders and the conventional treatment approaches, the review delves into the liposomal structure and composition. Moreover, it tackles the different mechanisms of liposomal targeting including both passive and active strategies. After that, the review moves on to explore the therapeutic potentials of liposomal nanocarriers in treating liver cirrhosis, fibrosis, viral hepatitis, and hepatocellular carcinoma. Through discussing recent advancements and envisioning future perspectives, this review highlights the role of liposomal nanocarriers in enhancing the effectiveness and the safety of liver disorders and consequently improving patient outcomes and enhances life quality.

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纳米脂质体载体介导的肝脏疾病靶向治疗：机制与应用。

肝脏疾病是全球健康面临的重大挑战，因此有必要探索创新的治疗方法。脂质体纳米载体已成为肝脏靶向给药的理想候选药物。本综述全面探讨了脂质体纳米载体治疗各种肝脏疾病的机制和应用。首先讨论了肝脏疾病和传统治疗方法，然后深入探讨了脂质体的结构和组成。此外，它还探讨了脂质体靶向的不同机制，包括被动和主动策略。之后，综述继续探讨了脂质体纳米载体在治疗肝硬化、肝纤维化、病毒性肝炎和肝细胞癌方面的治疗潜力。通过讨论最新进展和展望未来前景，本综述强调了脂质体纳米载体在提高肝脏疾病治疗的有效性和安全性方面的作用，从而改善患者预后和提高生活质量。

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来源期刊

Journal of Liposome Research 生物-生化与分子生物学

CiteScore

10.50

自引率

2.30%

发文量

审稿时长

3 months

期刊介绍： The Journal of Liposome Research aims to publish original, high-quality, peer-reviewed research on the topic of liposomes and related systems, lipid-based delivery systems, lipid biology, and both synthetic and physical lipid chemistry. Reviews and commentaries or editorials are generally solicited and are editorially reviewed. The Journal also publishes abstracts and conference proceedings including those from the International Liposome Society. The scope of the Journal includes: Formulation and characterisation of systems Formulation engineering of systems Synthetic and physical lipid chemistry Lipid Biology Biomembranes Vaccines Emerging technologies and systems related to liposomes and vesicle type systems Developmental methodologies and new analytical techniques pertaining to the general area Pharmacokinetics, pharmacodynamics and biodistribution of systems Clinical applications. The Journal also publishes Special Issues focusing on particular topics and themes within the general scope of the Journal.