Loneliness and Resting-State Functional Brain Connectivity Among Older Adults: A Proportional Correlation.

IF 2.4 4区 医学 Q2 CLINICAL NEUROLOGY
Ayu Imai, Teruyuki Matsuoka, Daisuke Ueno, Jin Narumoto
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Abstract

Objective: Loneliness reportedly increases the risk of dementia, especially Alzheimer's disease (AD). The authors' previous study demonstrated associations between loneliness and structural abnormalities observed in early-stage AD. The present study examined associations between the brain's functional characteristics and loneliness among older adults with concerns about cognitive decline.

Methods: This single-center study included 43 participants (13 with amnestic mild cognitive impairment and 30 with normal cognition). Participants were assessed with the revised University of California Los Angeles (UCLA) Loneliness Scale and underwent resting-state functional MRI. Functional images were preprocessed with the CONN toolbox. The selected seeds were within brain regions reportedly associated with loneliness. One-sample general linear model analysis was performed to examine regressions of UCLA Loneliness Scale scores and functional connectivity between the seeds and regions of interest.

Results: The revised UCLA Loneliness Scale scores were positively correlated with functional connectivity between the right hippocampus and left lateral parietal lobe and were negatively correlated with functional connectivity between the left amygdala and left frontal operculum and between the left amygdala and right supramarginal gyrus. Analyses were adjusted for age, sex, and education and scores on the Mini-Mental State Examination and Clinical Dementia Rating scale.

Conclusions: Loneliness was associated with abnormal function of the hippocampus, parts of the parietal lobe and frontal cortex, and the amygdala. These findings may suggest a possible correlation between loneliness and neurological changes associated with dementia.

老年人的孤独感与静息状态大脑功能连接性:比例相关性
目的据报道,孤独会增加患痴呆症,尤其是阿尔茨海默病(AD)的风险。作者之前的研究表明,孤独感与早期老年痴呆症的结构异常之间存在关联。本研究探讨了大脑功能特征与担心认知能力下降的老年人的孤独感之间的关系:这项单中心研究包括 43 名参与者(13 名患有记忆力轻度认知障碍,30 名认知能力正常)。参与者接受了加州大学洛杉矶分校(UCLA)孤独感量表(Loneliness Scale)修订版的评估,并进行了静息态功能磁共振成像(resting-state functional MRI)检查。功能图像由 CONN 工具箱进行预处理。所选种子位于据报道与孤独感相关的大脑区域内。研究人员进行了单样本一般线性模型分析,以检验 UCLA 孤独量表得分与种子和相关区域之间功能连接的回归情况:结果:修订版加州大学洛杉矶分校孤独感量表得分与右侧海马和左侧顶叶之间的功能连接呈正相关,与左侧杏仁核和左侧额厣之间以及左侧杏仁核和右侧边上回之间的功能连接呈负相关。分析对年龄、性别、教育程度以及小型精神状态检查和临床痴呆评分量表的得分进行了调整:结论:孤独与海马、顶叶和额叶皮层的部分区域以及杏仁核的功能异常有关。这些研究结果表明,孤独与痴呆症相关的神经系统变化之间可能存在关联。
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来源期刊
CiteScore
5.30
自引率
3.40%
发文量
67
审稿时长
6-12 weeks
期刊介绍: As the official Journal of the American Neuropsychiatric Association, the premier North American organization of clinicians, scientists, and educators specializing in behavioral neurology & neuropsychiatry, neuropsychology, and the clinical neurosciences, the Journal of Neuropsychiatry and Clinical Neurosciences (JNCN) aims to publish works that advance the science of brain-behavior relationships, the care of persons and families affected by neurodevelopmental, acquired neurological, and neurodegenerative conditions, and education and training in behavioral neurology & neuropsychiatry. JNCN publishes peer-reviewed articles on the cognitive, emotional, and behavioral manifestations of neurological conditions, the structural and functional neuroanatomy of idiopathic psychiatric disorders, and the clinical and educational applications and public health implications of scientific advances in these areas. The Journal features systematic reviews and meta-analyses, narrative reviews, original research articles, scholarly considerations of treatment and educational challenges in behavioral neurology & neuropsychiatry, analyses and commentaries on advances and emerging trends in the field, international perspectives on neuropsychiatry, opinions and introspections, case reports that inform on the structural and functional bases of neuropsychiatric conditions, and classic pieces from the field’s rich history.
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