Intersecting Blood Cytokines With Cholesterol Parameters to Profile Patients With Advanced Solid Tumors Receiving Immune Checkpoint Inhibitors.

IF 3.2 4区 医学 Q3 IMMUNOLOGY
Journal of Immunotherapy Pub Date : 2024-11-01 Epub Date: 2024-07-11 DOI:10.1097/CJI.0000000000000534
Giulia Mazzaschi, Fabiana Perrone, Giuseppe Maglietta, Elda Favari, Michela Verzè, Monica Pluchino, Roberta Minari, Federica Pecci, Letizia Gnetti, Nicoletta Campanini, Enrico Maria Silini, Massimo De Filippo, Michele Maffezzoli, Giulia Claire Giudice, Irene Testi, Marcello Tiseo, Federico Quaini, Sebastiano Buti
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引用次数: 0

Abstract

The study investigated the relationship between serum proinflammatory cytokine levels, cholesterol metabolism, and clinical outcome in cancer patients undergoing immune checkpoint inhibitors (ICIs). Peripheral blood was collected before therapy from ICI-treated advanced cancer patients. We retrospectively assessed plasma total cholesterol (TC), ABCA1- and ABCG1-mediated cholesterol efflux (CE), passive diffusion (PD), cholesterol loading capacity (CLC), and serum IL-6, IL-10, and TNF-α. The association between blood cholesterol parameters and inflammatory cytokines and their effect on overall survival (OS), progression-free survival (PFS), and clinical benefit (CB) from ICIs were statistically assessed. Among 70 consecutively enrolled patients (nonsmall cell lung cancer: 94%; renal cell carcinoma: 6%), TC, CLC, and cholesterol PD resulted significantly higher in IL-6 low and IL-10 low cases ( P <0.05), whereas ABCA1-mediated CE was increased in IL-10 high patients ( P =0.018). Uni- and multivariable analysis revealed meaningfully longer OS and PFS in IL-6 low (HR 2.13 and 2.97, respectively) and IL-10 low (HR 3.17 and 2.62) groups. At univariate analysis all cholesterol-related indices significantly correlated with OS and PFS, whereas at multivariate only high PD was validated as a protection factor (OS, HR 0.75; PFS, HR 0.84). Finally, uni- and multivariable showed a statistically significant inverse association of CB with ABCG1-CE (OR 0.62), as with IL-6 (OR 0.13) and IL-10 (OR 0.10). In-depth characterization of the interplay between blood cholesterol metabolism and immune-inflammatory cytokines might provide novel insights into the complex relationship among cancer, inflammation, lipids profile, and response to immunotherapy.

通过血液细胞因子与胆固醇参数的交叉分析,对接受免疫检查点抑制剂治疗的晚期实体瘤患者进行特征描述。
该研究调查了接受免疫检查点抑制剂(ICIs)治疗的癌症患者的血清促炎细胞因子水平、胆固醇代谢与临床结果之间的关系。我们在接受 ICI 治疗的晚期癌症患者治疗前采集了他们的外周血。我们对血浆总胆固醇(TC)、ABCA1和ABCG1介导的胆固醇外流(CE)、被动扩散(PD)、胆固醇负荷能力(CLC)以及血清IL-6、IL-10和TNF-α进行了回顾性评估。对血液胆固醇参数和炎症细胞因子之间的关联及其对总生存期(OS)、无进展生存期(PFS)和 ICIs 临床获益(CB)的影响进行了统计评估。在 70 名连续入组的患者(非小细胞肺癌:94%;肾细胞癌:6%)中,IL-6 低和 IL-10 低病例的 TC、CLC 和胆固醇 PD 显著较高(P<0.05)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Immunotherapy
Journal of Immunotherapy 医学-免疫学
CiteScore
6.90
自引率
0.00%
发文量
79
审稿时长
6-12 weeks
期刊介绍: Journal of Immunotherapy features rapid publication of articles on immunomodulators, lymphokines, antibodies, cells, and cell products in cancer biology and therapy. Laboratory and preclinical studies, as well as investigative clinical reports, are presented. The journal emphasizes basic mechanisms and methods for the rapid transfer of technology from the laboratory to the clinic. JIT contains full-length articles, review articles, and short communications.
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