Clinical features and prognosis of conjunctival melanoma in Japanese patients.

IF 2.1 3区 医学 Q2 OPHTHALMOLOGY
Japanese Journal of Ophthalmology Pub Date : 2024-09-01 Epub Date: 2024-07-11 DOI:10.1007/s10384-024-01085-z
Mika Tanabe, Naohiko Funatsu, Masato Akiyama, Ken-Ichi Takaki, Yuya Fujii, Eiko Seki, Kanako Yamana, Hiroshi Yoshikawa, Koh-Hei Sonoda
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引用次数: 0

Abstract

Purpose: To evaluate the clinical features and prognosis of conjunctival melanoma in Japanese patients.

Study design: Retrospective observational case series.

Methods: Twenty patients (8 men and 12 women) diagnosed with conjunctival melanoma at a singlehospital between 2003 and 2017 were analyzed. Data on clinical presentation, sex, age, the affected eye, tumor location, tumor origin, tumor stage according to the American Joint Committee on Cancer staging system (eighth edition), treatment, outcomes, local recurrence, metastasis, and survival were extracted from the patients' medical records and reviewed.

Results: The mean age at diagnosis was 64.2 ± 14.8 years. Tumor locations at the first examination included the bulbar conjunctiva (n = 19), plica (n = 13), and fornix (n = 12). The tumor stage was T1 in 5 cases (25%), T2 in 12 cases (60%), T3 in 3 cases (15%), and T4 in none. The mean follow-up duration was 91.7 ± 46.0 months. The local recurrence rates at 1, 5, and 10 years were 5.0%, 18.8%, and 31.5%, respectively, whilst the metastasis rates were 5.0%, 25.6%, and 32.4%, respectively. Four of the 6 patients who experienced metastasis died; duration from metastasis to death was 17.5 months (range, 7-25). The 5-year survival rate for conjunctival melanoma was 78.8%. Tumor thickness was significantly associated with survival duration on univariate Cox regression analyses.

Conclusion: The mortality rate for conjunctival melanoma in the Japanese population was lower and higher than that reported in the Chinese and United States populations, respectively. Tumor thickness was a prognostic factor for survival in patients with conjunctival melanoma.

Abstract Image

日本结膜黑色素瘤患者的临床特征和预后。
目的:评估日本结膜黑色素瘤患者的临床特征和预后:研究方法:回顾性观察病例系列:对 2003 年至 2017 年期间在一家医院确诊为结膜黑色素瘤的 20 例患者(男性 8 例,女性 12 例)进行分析。从患者的病历中提取并回顾了临床表现、性别、年龄、患眼、肿瘤位置、肿瘤来源、根据美国癌症联合委员会分期系统(第八版)进行的肿瘤分期、治疗、疗效、局部复发、转移和生存率等数据:患者确诊时的平均年龄为(64.2 ± 14.8)岁。首次检查的肿瘤位置包括球结膜(19 例)、板状结膜(13 例)和穹窿(12 例)。肿瘤分期为T1期5例(25%),T2期12例(60%),T3期3例(15%),T4期无。平均随访时间为 91.7 ± 46.0 个月。1年、5年和10年的局部复发率分别为5.0%、18.8%和31.5%,转移率分别为5.0%、25.6%和32.4%。6名发生转移的患者中有4人死亡,从转移到死亡的时间为17.5个月(7-25个月)。结膜黑色素瘤的 5 年生存率为 78.8%。在单变量考克斯回归分析中,肿瘤厚度与存活时间明显相关:结论:日本人结膜黑色素瘤的死亡率分别低于中国人和美国人。肿瘤厚度是影响结膜黑色素瘤患者生存期的一个预后因素。
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来源期刊
CiteScore
4.80
自引率
8.30%
发文量
65
审稿时长
6-12 weeks
期刊介绍: The Japanese Journal of Ophthalmology (JJO) was inaugurated in 1957 as a quarterly journal published in English by the Ophthalmology Department of the University of Tokyo, with the aim of disseminating the achievements of Japanese ophthalmologists worldwide. JJO remains the only Japanese ophthalmology journal published in English. In 1997, the Japanese Ophthalmological Society assumed the responsibility for publishing the Japanese Journal of Ophthalmology as its official English-language publication. Currently the journal is published bimonthly and accepts papers from authors worldwide. JJO has become an international interdisciplinary forum for the publication of basic science and clinical research papers.
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