The role of extracellular vesicles in pyroptosis-mediated infectious and non-infectious diseases.

IF 4.8 2区医学 Q2 IMMUNOLOGY

International immunopharmacology Pub Date : 2024-09-10 Epub Date: 2024-07-09 DOI:10.1016/j.intimp.2024.112633

Cai-Hua Zhang, Ding-Ci Lu, Ying Liu, Lingzhi Wang, Gautam Sethi, Zhaowu Ma

引用次数: 0

Abstract

Pyroptosis, a lytic and pro-inflammatory cell death, is important in various pathophysiological processes. Host- and bacteria-derived extracellular vesicles (EVs), as natural nanocarriers messengers, are versatile mediators of intercellular communication between different types of cells. Recently, emerging research has suggested that EVs exhibit multifaceted roles in disease progression by manipulating pyroptosis. This review focuses on new findings concerning how EVs shape disease progression in infectious and non-infectious diseases by regulating pyroptosis. Understanding the characteristics and activity of EVs-mediated pyroptotic death may conducive to the discovery of novel mechanisms and more efficient therapeutic targets in infectious and non-infectious diseases.

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细胞外囊泡在由热渗透介导的传染性和非传染性疾病中的作用。

细胞凋亡是一种溶解性和促炎性细胞死亡，在各种病理生理过程中都很重要。宿主和细菌衍生的细胞外囊泡（EVs）作为天然的纳米载体信使，是不同类型细胞之间进行细胞间交流的多功能媒介。最近，新出现的研究表明，细胞外囊泡通过操纵化脓过程在疾病进展中发挥着多方面的作用。本综述将重点探讨有关 EVs 如何通过调控化脓过程来影响感染性和非感染性疾病进展的新发现。了解EVs介导的化脓性死亡的特征和活性可能有助于发现传染性和非传染性疾病的新机制和更有效的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International immunopharmacology 医学-免疫学

CiteScore

8.40

自引率

3.60%

发文量

935

审稿时长

53 days

期刊介绍： International Immunopharmacology is the primary vehicle for the publication of original research papers pertinent to the overlapping areas of immunology, pharmacology, cytokine biology, immunotherapy, immunopathology and immunotoxicology. Review articles that encompass these subjects are also welcome. The subject material appropriate for submission includes: • Clinical studies employing immunotherapy of any type including the use of: bacterial and chemical agents; thymic hormones, interferon, lymphokines, etc., in transplantation and diseases such as cancer, immunodeficiency, chronic infection and allergic, inflammatory or autoimmune disorders. • Studies on the mechanisms of action of these agents for specific parameters of immune competence as well as the overall clinical state. • Pre-clinical animal studies and in vitro studies on mechanisms of action with immunopotentiators, immunomodulators, immunoadjuvants and other pharmacological agents active on cells participating in immune or allergic responses. • Pharmacological compounds, microbial products and toxicological agents that affect the lymphoid system, and their mechanisms of action. • Agents that activate genes or modify transcription and translation within the immune response. • Substances activated, generated, or released through immunologic or related pathways that are pharmacologically active. • Production, function and regulation of cytokines and their receptors. • Classical pharmacological studies on the effects of chemokines and bioactive factors released during immunological reactions.