Vitamin B12-Related Biomarkers.

IF 1.8 4区医学 Q3 FOOD SCIENCE & TECHNOLOGY

Food and Nutrition Bulletin Pub Date : 2024-06-01 DOI:10.1177/03795721241227114

Ebba Nexo, Tina Parkner

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引用次数: 0

Abstract

Background: Adult vitamin B12 (B12) deficiency may present itself with nonspecific mainly neurological symptoms, and thus plasma biomarkers are often judged to be of major importance in the further diagnostic process. Four biomarkers are of special relevance: total B12, holotranscobalamin (the part of B12 bound to the active transport protein, transcobalamin, also named holoTC or active B12) and the 2 so-called metabolic markers that accumulate if B12 is lacking, methylmalonic acid (MMA) and homocysteine.

Objective: This article briefly reviews the inherent limitation of biomarkers, discusses its use in establishing the diagnosis and cause of B12 deficiency, and when following or discontinuing treatment with B12.

Methods: The review is based on published papers, but also on knowledge gained from working within the area.

Conclusion: It is concluded that a combination of a B12 and a metabolic marker, for example, total B12 and MMA, may prove most useful in daily practice. An unexpectedly high level of total B12 is most often of no clinical importance, though sometimes related to the presence of underlying cancer. Measurement of total B12 is of limited value in patients on treatment with pharmacological doses of B12 but may be helpful if B12 treatment is discontinued.

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维生素 B12 相关生物标志物

背景：成人维生素 B12（B12）缺乏症可能表现为主要是神经系统的非特异性症状，因此血浆生物标志物通常被认为在进一步诊断过程中具有重要意义。四种生物标志物具有特殊的相关性：总 B12、全转钴胺（与活性转运蛋白结合的部分 B12，即转钴胺，也称为全转运蛋白或活性 B12）和两种所谓的代谢标志物，即甲基丙二酸（MMA）和同型半胱氨酸，如果缺乏 B12，这两种标志物就会累积：本文简要回顾了生物标记物的固有局限性，讨论了生物标记物在确定 B12 缺乏症的诊断和病因时的用途，以及在使用或停止 B12 治疗时的用途：方法：本综述基于已发表的论文，也基于在该领域工作中获得的知识：结论：B12 和代谢标志物（如总 B12 和 MMA）的组合在日常实践中可能最有用。总 B12 意外偏高通常没有临床意义，但有时与潜在癌症有关。对于正在接受药物剂量 B12 治疗的患者，测量总 B12 的价值有限，但在停止 B12 治疗时可能会有所帮助。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food and Nutrition Bulletin 工程技术-食品科技

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

18-36 weeks

期刊介绍： The Food and Nutrition Bulletin (FNB,) is a peer-reviewed, academic journal published quarterly by the Nevin Scrimshaw International Nutrition Foundation. The Journal is one of the leading resources used by researchers, academics, nutrition policy makers and planners in over 125 countries to obtain the most current research and policy information related to nutrition in developing countries.