Itaconate targets fibroblast-like synoviocytes in RA

IF 29.4 1区医学 Q1 RHEUMATOLOGY

Nature Reviews Rheumatology Pub Date : 2024-07-10 DOI:10.1038/s41584-024-01142-4

Sarah Onuora

引用次数: 0

Abstract

Treatment with the endogenous metabolite itaconate induced phenotypic and metabolic changes in fibroblast-like synoviocytes and reduced the severity of arthritis in an animal model.

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伊塔康酸可靶向治疗风湿性关节炎的成纤维细胞样滑膜细胞

用内源性代谢物伊它康酸治疗可诱导成纤维细胞样滑膜细胞的表型和代谢变化，并减轻动物模型中关节炎的严重程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Rheumatology 医学-风湿病学

CiteScore

29.90

自引率

0.90%

发文量

137

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Rheumatology is part of the Nature Reviews portfolio of journals. The journal scope covers the entire spectrum of rheumatology research. We ensure that our articles are accessible to the widest possible audience.