Expanding telmisartan’s therapeutic horizon: exploring its multifaceted mechanisms beyond cardiovascular disorders

IF 3.4 Q2 PHARMACOLOGY & PHARMACY
Yogesh S. Ahire, Vinod A. Bairagi, Deepak B. Somavanshi, Smruti R. Jadhav, Swapnil B. Jadhav, Shekhar D. Jagtap
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引用次数: 0

Abstract

Background

Telmisartan, a potent angiotensin II type-1 receptor blocker as well as partial PPAR–gamma agonist, has emerged as a versatile therapeutic agent with diverse pharmacological actions beyond its primary indication for essential hypertension. This review explores the complex mechanisms of action of telmisartan and clarifies its effectiveness in an inflammation, cancer, metabolic, and CNS disorders.

Main body

Telmisartan inhibits many biochemical processes involved in the control of the cardiovascular system, such as vascular smooth muscle contraction, aldosterone production, and sympathetic tone modulation, by specifically targeting the angiotensin II type-1 receptor. Its distinct partial agonist action toward peroxisome proliferator-activated receptor gamma also imparts anti-inflammatory, antiproliferative, and antioxidant activities, making it a viable treatment for various diabetic patients who have atherosclerosis and myocardial infarction.

Conclusion

Telmisartan's diverse pharmacological actions, encompassing anti-inflammatory, neuroprotective, nephroprotective, anticancer, and anti-anxiety properties, position it as a promising treatment option for a broad spectrum of medical conditions.

拓展替米沙坦的治疗范围:探索其超越心血管疾病的多方面机制
替米沙坦是一种强效的血管紧张素II-1型受体阻断剂,也是PPAR-γ的部分激动剂,它已成为一种多功能治疗药物,除了主要用于治疗原发性高血压外,还具有多种药理作用。本综述探讨了替米沙坦复杂的作用机制,并阐明了其在炎症、癌症、代谢和中枢神经系统疾病中的有效性。替米沙坦通过特异性靶向血管紧张素II-1型受体,抑制许多参与心血管系统控制的生化过程,如血管平滑肌收缩、醛固酮分泌和交感神经张力调节。它对过氧化物酶体增殖激活受体γ具有独特的部分激动作用,还具有抗炎、抗增殖和抗氧化活性,因此是治疗动脉粥样硬化和心肌梗死等糖尿病患者的一种可行药物。替米沙坦具有多种药理作用,包括抗炎、神经保护、肾保护、抗癌和抗焦虑等特性,因此有望成为治疗多种疾病的一种选择。
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来源期刊
自引率
0.00%
发文量
44
审稿时长
23 weeks
期刊介绍: Future Journal of Pharmaceutical Sciences (FJPS) is the official journal of the Future University in Egypt. It is a peer-reviewed, open access journal which publishes original research articles, review articles and case studies on all aspects of pharmaceutical sciences and technologies, pharmacy practice and related clinical aspects, and pharmacy education. The journal publishes articles covering developments in drug absorption and metabolism, pharmacokinetics and dynamics, drug delivery systems, drug targeting and nano-technology. It also covers development of new systems, methods and techniques in pharmacy education and practice. The scope of the journal also extends to cover advancements in toxicology, cell and molecular biology, biomedical research, clinical and pharmaceutical microbiology, pharmaceutical biotechnology, medicinal chemistry, phytochemistry and nutraceuticals.
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