Injectable Hydrogels for Intratumoral Administration Against Breast Cancer

IF 4.7 3区 工程技术 Q2 ENGINEERING, ENVIRONMENTAL
Elnaz Bagheri, Mohammad Ramezani, Marzieh Mohammadi, Mona Alibolandi
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Abstract

Breast cancer poses a significant health risk and remains the most prevalent cancer among women. The side effects associated with traditional chemotherapy, such as neurotoxicity, liver or kidney dysfunction, highlight the urgent need for novel breast cancer therapies. In this regard, local delivery of chemotherapeutics has been emerged to be one of the efficient methods to eradicate the tumor cells. Injectable hydrogels were developed as drug delivery systems for localized drug accumulation and controlled drug release at the tumor site. Hydrogels are 3D network of polymeric structures with notable biocompatibility, swelling properties and mechanical strength. In fact, an injectable hydrogel enhances drug delivery efficiency, reduces systemic drug cytotoxicity, minimizes the essential drug dosage and frequency of drug administration. The studies based on injectable hydrogels for specific cancer therapy showed that such platforms are more effective and durable methods than traditional chemotherapy. Additionally, they are vastly used in inhibiting postsurgical tumor recurrence. These hydrogel platforms can integrate multiple breast cancer therapies into a single structure to improve the treatment efficacy. In this review, a variety of injectable hydrogel drug delivery platforms were discussed for several types of applications, such as gene therapy, drug delivery, immunotherapy, photothermal therapy, photodynamic therapy, and combined therapies with synergistic effects against breast cancer. Moreover, we provided a brief summary of the recent advances in the application of such hydrogels for breast cancer treatment. This review provides insight into the recent advancements in injectable hydrogels and discusses the potential future applications and challenges associated with this drug delivery technology toward cancer therapy.

Abstract Image

Abstract Image

用于乳腺癌瘤内给药的可注射水凝胶
乳腺癌对健康构成重大威胁,仍然是女性中发病率最高的癌症。传统化疗的副作用,如神经毒性、肝肾功能障碍等,凸显了对新型乳腺癌疗法的迫切需求。在这方面,局部给药化疗已成为根除肿瘤细胞的有效方法之一。可注射的水凝胶被开发为药物输送系统,用于在肿瘤部位进行局部药物蓄积和控制药物释放。水凝胶是三维网络聚合物结构,具有显著的生物相容性、溶胀特性和机械强度。事实上,可注射水凝胶能提高给药效率,降低全身药物的细胞毒性,最大限度地减少必要的药物剂量和给药频率。基于可注射水凝胶的特定癌症治疗研究表明,这种平台比传统化疗方法更有效、更持久。此外,它们还被广泛用于抑制手术后肿瘤复发。这些水凝胶平台可将多种乳腺癌疗法整合到单一结构中,从而提高治疗效果。本综述讨论了多种可注射水凝胶给药平台的应用,如基因治疗、给药、免疫治疗、光热治疗、光动力治疗以及对乳腺癌有协同作用的联合疗法。此外,我们还简要总结了应用此类水凝胶治疗乳腺癌的最新进展。本综述深入探讨了可注射水凝胶的最新进展,并讨论了这种药物输送技术在癌症治疗方面的未来潜在应用和相关挑战。
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来源期刊
Journal of Polymers and the Environment
Journal of Polymers and the Environment 工程技术-高分子科学
CiteScore
9.50
自引率
7.50%
发文量
297
审稿时长
9 months
期刊介绍: The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.
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